Overexpression of FRAT1 Is Associated with Malignant Phenotype and Poor Prognosis in Human Gliomas

Figure 2

Comparison of the FRAT1 IRS, Pi, Ii, and MVD for glioma specimens of increasing WHO grades. The FRAT1 immunoreactivity score (FRAT1 IRS) (a), the proliferative index (Pi) (b), the invasive index (Ii) (c), and the microvessel density (MVD) (d) were based on the staining results of FRAT1, PCNA, MMP-9, and CD34, respectively. Each of these scores increased significantly with ascending pathologic grade ().

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