Table 4: Risk factors in ICC patients for overall survival by Cox multivariate analysis.

FactorsSubgroups HR (95% CI) value

Age (years) >653.881 (1.301–11.581)0.01
≤65Ref.

PostopCA19-9 (U/mL)Elevated (>37)114.41 (2.01–6.72)<0.001
Normalized (≤37)63Ref.

Perineural invasion(+)453.073 (1.255–7.521)0.01
(−)29Ref.

Resection margin≤1 cm433.152 (1.115–8.908)0.05
>1 cm21Ref.

Lymph node metastasis(+)203.427 (1.346–8.723)0.02
(−)54Ref.

ICC: intrahepatic cholangiocarcinoma; postopCA19-9: postoperative lowest CA19-9.