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Disease Markers
Volume 2015, Article ID 301781, 7 pages
Research Article

Immunohistochemical Expression of Survivin and Its Relationship with Cell Apoptosis and Proliferation in Ameloblastomas

1Research Department, School of Dentistry, Universidad Juárez del Estado de Durango (UJED), 34000 Durango, Mexico
2Doctorado en Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, 04960 Mexico City, Mexico
3Health Care Department, Universidad Autónoma Metropolitana, Xochimilco, 04960 Mexico City, Mexico
4Department of Biology of Reproduction, Universidad Autónoma Metropolitana, Iztapalapa, 09340 Mexico City, Mexico
5Society for Fight Against Cancer, Portoviejo, 130105 Manabi, Ecuador
6National Institute of Oncology and Radiobiology, 10400 La Habana, Cuba
7School of Dentistry, Universidad de la República (UDELAR), 19200 Montevideo, Uruguay

Received 25 November 2014; Revised 25 February 2015; Accepted 9 March 2015

Academic Editor: Lance A. Liotta

Copyright © 2015 Rogelio González-González et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Ameloblastoma behavior is related to the potential of tumor cells to inhibit apoptosis and to initiate a proliferative phase. This study was performed to compare the immunoexpression of Survivin with Bcl-2, Bax, and Ki-67 and to associate them with the histopathological type of each variant of ameloblastoma. Material and Methods. Using the World Health Organization (WHO) criteria for ameloblastoma, 110 cases were selected. The cases were classified as solid/multicystic and unicystic ameloblastomas. Cellular counts of cytoplasmic immunoexpression were assessed for cytoplasmic Survivin, Bcl-2, and Bax, while the nuclear immunoexpression of Survivin and Ki-67 was assessed using label index. Results. Cytoplasmic Survivin and Bcl-2 showed higher percentages of immunoexpression in solid multicystic ameloblastomas compared to unicystic ameloblastomas (). Bax, Ki-67, and nuclear Survivin were expressed in higher percentages in unicystic ameloblastomas. Conclusions. Cytoplasmic Survivin and Bcl-2 immunoexpression levels were elevated in relation to Bax immunoexpression, suggesting aggressive ameloblastoma behavior, while Ki-67 and nuclear Survivin immunoexpression may be associated with the type of tumor morphology that influences cellular counts or with the greater capacity for cellular proliferation and tumor growth.