Table of Contents Author Guidelines Submit a Manuscript
Disease Markers
Volume 2015, Article ID 316182, 9 pages
http://dx.doi.org/10.1155/2015/316182
Research Article

The Expression of Notch/Notch Ligand, IL-35, IL-17, and Th17/Treg in Preeclampsia

1Department of Obstetrics, Maternity and Child Health Hospital of Zhenjiang, No. 20 Zhengdong Road, Zhenjiang, Jiangsu 212001, China
2Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China
3Central Laboratory of Medicine, Maternity and Child Health Hospital of Zhenjiang, No. 20 Zhengdong Road, Zhenjiang, Jiangsu 212001, China
4Obstetrics and Gynecology, The Affiliated People Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, China
5Laboratory of Medicine, Maternity and Child Health Hospital of Zhenjiang, No. 20 Zhengdong Road, Zhenjiang, Jiangsu 212001, China

Received 13 February 2015; Revised 20 April 2015; Accepted 27 April 2015

Academic Editor: Maddalena Ruggieri

Copyright © 2015 Weiping Cao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Le, Obstetrics and Gynecology, People's Medical Publishing House, Beijing, China, 7th edition, 2008, (Chinese).
  2. F. G. Cunningham and J. W. Williams, Eds., Williams Obstetrics, McGraw-Hill Medical, New York, NY, USA, 23rd edition, 2010.
  3. M. Comabella and S. J. Khoury, “Immunopathogenesis of multiple sclerosis,” Clinical Immunology, vol. 142, no. 1, pp. 2–8, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Saito, A. Nakashima, T. Shima, and M. Ito, “Th1/Th2/Th17 and Regulatory T-cell paradigm in pregnancy,” The American Journal of Reproductive Immunology, vol. 63, no. 6, pp. 601–610, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. W. Cao, W. Xu, T. Chen et al., “CD4+CD25+FoxP3+ regulatory T cells and cytokines interact with estradiol in cases of missed abortion,” Experimental and Therapeutic Medicine, vol. 7, no. 2, pp. 417–422, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Erlebacher, “Mechanisms of T cell tolerance towards the allogeneic fetus,” Nature Reviews Immunology, vol. 13, no. 1, pp. 23–33, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. R. M. Samstein, S. Z. Josefowicz, A. Arvey, P. M. Treuting, and A. Y. Rudensky, “Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict,” Cell, vol. 150, no. 1, pp. 29–38, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. L. W. Collison, C. J. Workman, T. T. Kuo et al., “The inhibitory cytokine IL-35 contributes to regulatory T-cell function,” Nature, vol. 450, no. 7169, pp. 566–569, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. Z. S. Ozkan, M. Simsek, F. Ilhan, D. Deveci, A. Godekmerdan, and E. Sapmaz, “Plasma IL-17, IL-35, interferon-γ, SOCS3 and TGF-β levels in pregnant women with preeclampsia, and their relation with severity of disease,” The Journal of Maternal-Fetal & Neonatal Medicine, vol. 27, no. 15, pp. 1513–1517, 2014. View at Publisher · View at Google Scholar
  10. G. S. Whitehead, R. H. Wilson, K. Nakano, L. H. Burch, H. Nakano, and D. N. Cook, “IL-35 production by inducible costimulator (ICOS)-positive regulatory T cells reverses established IL-17-dependent allergic airways disease,” Journal of Allergy and Clinical Immunology, vol. 129, no. 1, pp. 207–215, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Q. Crome, A. Y. Wang, and M. K. Levings, “Translational mini-review series on Th17 cells: function and regulation of human T helper 17 cells in health and disease,” Clinical and Experimental Immunology, vol. 159, no. 2, pp. 109–119, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Banchereau, V. Pascual, and A. O'Garra, “From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines,” Nature Immunology, vol. 13, no. 10, pp. 925–931, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. E. Laresgoiti-Servitje, “A leading role for the immune system in the pathophysiology of preeclampsia,” Journal of Leukocyte Biology, vol. 94, no. 2, pp. 247–257, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Saito, “Th17 cells and regulatory T cells: new light on pathophysiology of preeclampsia,” Immunology and Cell Biology, vol. 88, no. 6, pp. 615–617, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. D. Darmochwal-Kolarz, M. Kludka-Sternik, J. Tabarkiewicz et al., “The predominance of Th17 lymphocytes and decreased number and function of Treg cells in preeclampsia,” Journal of Reproductive Immunology, vol. 93, no. 2, pp. 75–81, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. F. Radtke, N. Fasnacht, and H. R. MacDonald, “Notch signaling in the immune system,” Immunity, vol. 32, no. 1, pp. 14–27, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. T. Taghon, E. Waegemans, and I. Van de Walle, “Notch signaling during human T cell development,” Microbiology and Immunology, vol. 360, pp. 75–97, 2012. View at Google Scholar
  18. F. Radtke, H. R. MacDonald, and F. Tacchini-Cottier, “Regulation of innate and adaptive immunity by Notch,” Nature Reviews Immunology, vol. 13, no. 6, pp. 427–437, 2013. View at Google Scholar · View at Scopus
  19. V. Chaturvedi, L. W. Collison, C. S. Guy, C. J. Workman, and D. A. A. Vignali, “Cutting edge: human regulatory T cells require IL-35 to mediate suppression and infectious tolerance,” Journal of Immunology, vol. 186, no. 12, pp. 6661–6666, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. L. W. Collison, V. Chaturvedi, A. L. Henderson et al., “IL-35-mediated induction of a potent regulatory T cell population,” Nature Immunology, vol. 11, no. 12, pp. 1093–1101, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. J. R. Prins, H. M. Boelens, J. Heimweg et al., “Preeclampsia is associated with lower percentages of regulatory T cells in maternal blood,” Hypertension in Pregnancy, vol. 28, no. 3, pp. 300–311, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Kassan, A. Wecker, P. Kadowitz, M. Trebak, and K. Matrougui, “CD4+CD25+Foxp3 regulatory T cells and vascular dysfunction in hypertension,” Journal of Hypertension, vol. 31, no. 10, pp. 1939–1943, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Kassan, A. Wecker, P. Kadowitz, M. Trebak, and K. Matrougui, “CD4+CD25+Foxp3 regulatory T cells and vascular dysfunction in hypertension,” Journal of Hypertension, vol. 31, no. 10, pp. 1939–1943, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. D. Hanidziar and M. Koulmanda, “Inflammation and the balance of Treg and Th17 cells in transplant rejection and tolerance,” Current Opinion in Organ Transplantation, vol. 15, no. 4, pp. 411–415, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. D. R. Littman and A. Y. Rudensky, “Th17 and regulatory T cells in mediating and restraining inflammation,” Cell, vol. 140, no. 6, pp. 845–858, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. Y. Sasaki, D. Darmochwal-Kolarz, D. Suzuki et al., “Proportion of peripheral blood and decidual CD4+CD25bright regulatory T cells in pre-eclampsia,” Clinical and Experimental Immunology, vol. 149, no. 1, pp. 139–145, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. I. K. Gratz, M. D. Rosenblum, M. M. Maurano et al., “Cutting edge: self-antigen controls the balance between effector and regulatory T cells in peripheral tissues,” The Journal of Immunology, vol. 192, no. 4, pp. 1351–1355, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. G. Toldi, A. Molvarec, B. Stenczer et al., “Peripheral Th1/Th2/Th17/regulatory T-cell balance in asthmatic pregnancy,” International Immunology, vol. 23, no. 11, pp. 669–677, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. A. Steinborn, G. M. Haensch, K. Mahnke et al., “Distinct subsets of regulatory T cells during pregnancy: is the imbalance of these subsets involved in the pathogenesis of preeclampsia?” Clinical Immunology, vol. 129, no. 3, pp. 401–412, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. B. Santner-Nanan, M. J. Peek, R. Khanam et al., “Systemic increase in the ratio between Foxp3+ and IL-17-producing CD4+ T cells in healthy pregnancy but not in preeclampsia,” The Journal of Immunology, vol. 183, no. 11, pp. 7023–7030, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. S. M. Carlin, M. L. M. Khoo, D. D. Ma, and J. J. Moore, “Notch signaling inhibits CD4 expression during initiation and differentiation of human T cell lineage,” PLoS ONE, vol. 7, no. 10, Article ID e45342, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. F. Auderset, M. Coutaz, and F. Tacchini-Cottier, “The role of notch in the differentiation of CD4+ T helper cells,” Current Topics in Microbiology and Immunology, vol. 360, pp. 115–134, 2012. View at Publisher · View at Google Scholar · View at Scopus
  33. D. Amsen, A. Antov, and R. A. Flavell, “The different faces of Notch in T-helper-cell differentiation,” Nature Reviews Immunology, vol. 9, no. 2, pp. 116–124, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Artavanis-Tsakonas and M. A. T. Muskavitch, “Notch: the past, the present, and the future,” Current Topics in Developmental Biology, vol. 92, pp. 1–29, 2010. View at Publisher · View at Google Scholar · View at Scopus