Table of Contents Author Guidelines Submit a Manuscript
Disease Markers
Volume 2015, Article ID 345080, 7 pages
http://dx.doi.org/10.1155/2015/345080
Research Article

Hypermethylation-Associated Silencing of miR-125a and miR-125b: A Potential Marker in Colorectal Cancer

1Department of Gastroenterology, People’s Hospital of Taizhou, 399 Hailing Road, Taizhou, Jiangsu 225300, China
2Department of Gastroenterology, Second Xiangya Hospital, Central South University, 139 Renmin Middle Road, Changsha, Hunan 410011, China

Received 5 September 2015; Revised 11 November 2015; Accepted 12 November 2015

Academic Editor: Stamatios Theocharis

Copyright © 2015 Hui Chen and Zhiying Xu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Goel and C. R. Boland, “Epigenetics of colorectal cancer,” Gastroenterology, vol. 143, no. 6, pp. 1442–1460.e1, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. W. M. Grady and J. M. Carethers, “Genomic and epigenetic instability in colorectal cancer pathogenesis,” Gastroenterology, vol. 135, no. 4, pp. 1079–1099, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. L. He and G. J. Hannon, “MicroRNAs: small RNAs with a big role in gene regulation,” Nature Reviews Genetics, vol. 5, no. 7, pp. 522–531, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. M. V. Iorio and C. M. Croce, “MicroRNAs in cancer: small molecules with a huge impact,” Journal of Clinical Oncology, vol. 27, no. 34, pp. 5848–5856, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. C. E. Stahlhut Espinosa and F. J. Slack, “The role of microRNAs in cancer,” Yale Journal of Biology and Medicine, vol. 79, no. 3-4, pp. 131–140, 2006. View at Google Scholar · View at Scopus
  6. A. Esquela-Kerscher and F. J. Slack, “Oncomirs—microRNAs with a role in cancer,” Nature Reviews Cancer, vol. 6, no. 4, pp. 259–269, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. E. Bandres, X. Agirre, N. Bitarte et al., “Epigenetic regulation of microRNA expression in colorectal cancer,” International Journal of Cancer, vol. 125, no. 11, pp. 2737–2743, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. H. Siemens, J. Neumann, R. Jackstadt et al., “Detection of miR-34a promoter methylation in combination with elevated expression of c-Met and β-catenin predicts distant metastasis of colon cancer,” Clinical Cancer Research, vol. 19, no. 3, pp. 710–720, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. M. V. Iorio, M. Ferracin, C.-G. Liu et al., “MicroRNA gene expression deregulation in human breast cancer,” Cancer Research, vol. 65, no. 16, pp. 7065–7070, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. W. Li, L. Xie, X. He et al., “Diagnostic and prognostic implications of microRNAs in human hepatocellular carcinoma,” International Journal of Cancer, vol. 123, no. 7, pp. 1616–1622, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. N. Nishida, K. Mimori, M. Fabbri et al., “MicroRNA-125a-5p is an independent prognostic factor in gastric cancer and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab,” Clinical Cancer Research, vol. 17, no. 9, pp. 2725–2733, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. G. K. Scott, A. Goga, D. Bhaumik, C. E. Berger, C. S. Sullivan, and C. C. Benz, “Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b,” The Journal of Biological Chemistry, vol. 282, no. 2, pp. 1479–1486, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Visone, P. Pallante, A. Vecchione et al., “Specific microRNAs are downregulated in human thyroid anaplastic carcinomas,” Oncogene, vol. 26, no. 54, pp. 7590–7595, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. P. T. Nelson, D. A. Baldwin, W. P. Kloosterman, S. Kauppinen, R. H. A. Plasterk, and Z. Mourelatos, “RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain,” RNA, vol. 12, no. 2, pp. 187–191, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. R. L. Prueitt, M. Yi, R. S. Hudson et al., “Expression of microRNAs and protein-coding genes associated with perineural invasion in prostate cancer,” Prostate, vol. 68, no. 11, pp. 1152–1164, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. K. Reed, S. L. Hembruff, M. L. Laberge, D. J. Villeneuve, G. B. Côté, and A. M. Parissenti, “Hypermethylation of the ABCB1 downstream gene promoter accompanies ABCB1 gene amplification and increased expression in docetaxel-resistant MCF-7 breast tumor cells,” Epigenetics, vol. 3, no. 5, pp. 270–280, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. A. J. Schetter, S. Y. Leung, J. J. Sohn et al., “MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma,” The Journal of the American Medical Association, vol. 299, no. 4, pp. 425–436, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. Zhang, L.-X. Yan, Q.-N. Wu et al., “miR-125b is methylated and functions as a tumor suppressor by regulating the ETS1 proto-oncogene in human invasive breast cancer,” Cancer Research, vol. 71, no. 10, pp. 3552–3562, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. J. K. Kim, J. H. Noh, K. H. Jung et al., “Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b,” Hepatology, vol. 57, no. 3, pp. 1055–1067, 2013. View at Publisher · View at Google Scholar · View at Scopus