Replication of GWAS Coding SNPs Implicates MMEL1 as a Potential Susceptibility Locus among Saudi Arabian Celiac Disease Patients
Table 2
Genotype distributions and allele frequencies of examined polymorphism between patients and controls, as well as their prediction for celiac disease risk.
Gene
SNP ID
Genotype/allele
Cases (%)
Controls (%)
OR (95% CI)
IRAK1
rs1059702
AA
23 (23.71)
32 (25.8)
Reference
AG
24 (24.74)
38 (30.64)
0.1162
0.7321
0.87 (0.419–1.84)
GG
50 (51.54)
54 (43.54)
0.5639
0.4539
1.28 (0.66–2.49)
GG versus AG + AA
#
#
0.12
0.72
1.11 (0.60–2.07)
AA versus AG + GG
#
#
1.3
0.23
0.72 (0.42–1.23)
A
70 (36.08)
102 (41.12)
Reference
G
124 (63.91)
146 (58.87)
1.164
0.2815
1.238 (0.840–1.82)
SH2B3
rs3184504
TT
58 (59.79)
75 (60.48)
Reference
TC
36 (37.11)
42 (34.67)
0.077
0.78164
1.08 (0.618–1.895)
CC
3 (3.09)
5 (4.83)
0.361
0.54813
0.64 (0.155–2.695)
TT versus TC + CC
#
#
0.01
1
1.02 (0.59–1.77)
CC versus TC + TT
#
#
0.42
0.51
1.59 (0.38–6.54)
T
152 (78.3)
192 (78.68)
Reference
C
42 (21.7)
52 (21.31)
0.018
1
0.97 (0.616–1.527)
MMEL1
rs3748816
TT
38 (41.23)
55 (44.35)
Reference
TC
32 (32.98)
54 (43.54)
0.24
0.61
0.85 (0.47–1.56)
CC
27 (25.77)
15 (12.09)
6.31
0.01
2.60 (1.22–5.54)
CC versus TC + TT
#
#
0.59
0.43
1.23 (0.72–2.12)
TT versus CC + TC
#
#
8.71
0.03
0.35 (0.17–0.71)
T
108 (55.67)
164 (66.1)
Reference
C
86 (44.32)
84 (33.8)
5.01
0.02
1.55 (1.05–2.28)
Genotype values are mentioned in above corresponding rows; values are statistically significant.
