Research Article
Serum Levels of Progranulin Are Closely Associated with Microvascular Complication in Type 2 Diabetes
Table 3
Serum PGRN levels in DR.
| | NC | SDM | BDR | PDR |
| | 12 | 29 | 14 | 33 | Age (years) | 54.58 ± 9.56 | 58.86 ± 12.68 | 61.21 ± 8.44 | 60.85 ± 8.65 | Sex (male/female) | 7/5 | 18/11 | 8/6 | 19/14 | Duration of diabetes (years) | 0 | 1.77 ± 1.00 | 7.46 ± 3.91 | 11.09 ± 4.72 | SBP (mmHg) | 112.50 ± 10.31 | 127.93 ± 14.24 | 131.57 ± 20.05 | 149.18 ± 17.79 | DBP (mmHg) | 68.33 ± 7.90 | 76.21 ± 6.64 | 73.71 ± 6.88 | 88.33 ± 11.18 | BMI (kg/m2) | 20.97 ± 1.41 | 24.26 ± 2.04 | 25.01 ± 2.21 | 24.77 ± 1.70 | WHR | 0.84 ± 0.05 | 0.88 ± 0.05 | 0.91 ± 0.06 | 0.89 ± 0.05 | HbA1c (%) | 4.93 ± 0.42 | 10.20 ± 2.05 | 10.31 ± 2.21 | 9.25 ± 2.21 | FPG (mmol/L) | 4.53 ± 0.48 | 10.47 ± 2.58 | 10.86 ± 2.96 | 10.47 ± 3.07 | Lg(FINS) (mU/L) | 1.11 ± 0.12 | 1.27 ± 0.07 | 1.17 ± 0.09## | 1.18 ± 0.09## | Lg(HOMA-IR) | 0.42 ± 0.14 | 0.93 ± 0.13 | 0.84 ± 0.14 | 0.83 ± 0.15 | TG (mmol/L) | 1.40 ± 0.28 | 3.99 ± 1.54 | 3.94 ± 0.88 | 4.35 ± 1.94 | TC (mmol/L) | 3.81 ± 0.51 | 5.21 ± 1.09 | 5.26 ± 1.31 | 5.16 ± 1.10 | HDL-c (mmol/L) | 1.22 ± 0.12 | 0.96 ± 0.12 | 0.99 ± 0.09 | 0.98 ± 0.13 | LDL-c (mmol/L) | 2.22 ± 0.25 | 3.57 ± 0.79 | 3.92 ± 1.06 | 3.80 ± 0.96 | UAER (mg/24 h) | 24.55 ± 4.86 | 25.82 ± 3.99 | 233.14 ± 95.52 | 438.46 ± 176.82 | BUN (mmol/L) | 5.17 ± 0.80 | 5.23 ± 1.17 | 7.01 ± 1.84 | 9.09 ± 3.59 | CRE (μmol/L) | 66.75 ± 5.72 | 71.48 ± 12.37 | 86.45 ± 20.01 | 162.39 ± 80.37 | eGFR (mL/min/1.73 m2) | 109.27 ± 19.46 | 102.85 ± 25.32 | 80.04 ± 18.46 | 48.15 ± 27.40 | WBC (×109/L) | 5.58 ± 0.99 | 5.82 ± 0.99 | 6.67 ± 1.93 | 6.70 ± 1.44 | IL-6 (ng/L) | 8.03 ± 2.17 | 13.73 ± 4.38 | 17.06 ± 5.40 | 21.92 ± 5.64 | TNF-α (μg/L) | 10.74 ± 1.15 | 12.57 ± 3.29 | 17.72 ± 4.20 | 20.57 ± 5.45 | PGRN (μg/L) | 45.21 ± 4.75 | 47.18 ± 4.51 | 57.90 ± 6.17 | 82.30 ± 30.90 | ACEI or ARB, (%) | 0 (0%) | 2 (6.90%) | 2 (14.29%) | 16 (48.48%) | Oral antidiabetics, (%) | 0 (0%) | 27 (93.10%) | 11 (78.57%) | 23 (69.70%) | Insulin, (%) | 0 (0%) | 4 (13.79%) | 9 (64.29%) | 20 (60.61%) |
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NC: normal control. SDM: simple diabetes mellitus. BDR: background diabetic retinopathy. PDR: proliferative diabetic retinopathy. Compared with NC, , . Compared with SDM, #, ##. Compared with BDR, △, △△.
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