Polymorphisms rs12998 and rs5780218 in KiSS1 Suppressor Metastasis Gene in Mexican Patients with Breast Cancer

Table 3

Genotype frequencies for KiSS1 suppressor metastasis gene rs12998 and rs5780218 polymorphisms in three groups and statistical analysis between groups. BC: breast cancer; BCD: breast cancer disease; GP: general population.

Genotype frequency

Statistical analysis

Groups; ()

BC; (78)

BBD; (52)

GP; (90)

BC versus BBD

BC versus GP

BBD versus GP

BC + BBD versus GP

GG

GA

AA

GG

GA

AA

GG

GA

AA

rs12998

0.43

0.47

0.08

0.48

0.46

0.05

0.91

0.08

0

= 0.5660; P = 0.7688

= 44.92; P  = 0.0000

= 33.6018; P  = 0.0000

= 48.8025; P  = 0.0000

AA

A—

—

AA

A—

—

AA

A—

—

rs5780218

0.26

0.39

0.33

0.32

0.44

0.17

0.38

0.44

0.16

= 4.0800; P = 0.1368

= 6.7695; P  = 0.0332

= 0.5724; = 0.7751

= 3.9609; = 0.1415