Polymorphisms rs12998 and rs5780218 in KiSS1 Suppressor Metastasis Gene in Mexican Patients with Breast Cancer

Table 4

Haplotype distribution in patients with breast cancer (BC), breast cancer with metastasis (BC M), breast cancer without metastasis (BC NM), benign breast disease (BBD), and individuals from Mexican general population (GP). Wt: wild type. Haplotypes: H1–H4.

Group (/chromosomes)	Haplotype rs12998/rs5780218				Statistical analysis
	H1; Wt/variant	H2; Wt/Wt	H3; Variant/variant	H4; Variant/Wt	BC versus BBD	BC versus GP	BBD versus GP	BCM versus BC NM
BC (156)	0.4256	0.2474	0.1064	0.2205	= 21.9537; = 0.0002; (OR  =  3.32)	= 70.6430; = 0.0000; (OR  =  3)	= 0.5724; = 0.7801	= 10.5813; = 0.0130
BC M (32)	0.5101	0.1773	0.0836	0.2288
BC NM (26)	0.1431	0.4337	0.2799	0.1431
BBD (104)	0.2441	0.4673	0.1789	0.1095
GP (180)	0.3388	0.6166	0.0444	0