The Relationship between Clinical Feature, Complex Immunophenotype, Chromosome Karyotype, and Outcome of Patients with Acute Myeloid Leukemia in China
Table 1
Clinical features and biological characteristics of patients with MPAL, Ly+AML, and Ly−AML [ (%)].
MPAL
Ly+AML
Ly−AML
value
Total number of cases
47
60
90
Age (y)
Median
34
34.5
39.5
NS
Range
3~72
2~83
3~84
Sex
Male
30 (63.8)
33 (55)
55 (61.1)
NS
Female
17 (36.2)
27 (45)
35 (38.9)
WBC (×109/L)
Median
20.16
30.6
24.1
NS
Range
0.8~620
1.02~337.3
1~440.98
Blasts in BM (%)
Median
67.6
45.8
55.7
0.01
Range
28~90
20.8~88.5
20.42~95
Hepatosplenomegaly and lymphadenectasis
30 (63.8)
26 (43.3)
36 (40.0)
0.024
Immunophenotyping
CD34+
36 (76.6)
49 (81.7)
43 (47.8)
<0.001
CD117+
4 (8.5)
37 (61.7)
46 (51.1)
<0.001
HLA-DR+
36 (76.6)
51 (85.0)
67 (74.4)
NS
Karyotypic analysis ()
37
51
90
Normal
10 (27.0)
30 (58.8)
52 (57.8)
0.003
Complex
15 (40.5)
11 (21.6)
18 (20.0)
0.042
Abnormal
12 (32.4)
10 (19.6)
20 (22.2)
NS
Ph+
8 (21.6)
0 (0)
0 (0)
<0.001
FISH detection ()
34
53
73
BCR/ABL(+)
7 (20.6)
1 (1.9)
0 (0)
<0.001
AML1-ETO(+)
1 (2.9)
11 (20.8)
11 (15.1)
NS
MLL(+)
1 (2.9)
1 (1.9)
2 (2.7)
NS
Note. (1) Cases with chronic myeloid leukemia or myelodysplastic syndrome, acute promyelocytic leukemia, and secondary leukemia were excluded in this paper. (2) One-way ANOVA was applied for comparison measurement data like onset age and percentage of leukemia cells in BM and white blood cell count among the 3 groups. Chi-square test was used for comparison of other proportion. NS: no significance. WBC: white blood cell.
