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Disease Markers
Volume 2015, Article ID 382918, 6 pages
http://dx.doi.org/10.1155/2015/382918
Review Article

Uric Acid as a Marker of Kidney Disease: Review of the Current Literature

1Department of Internal Medicine, University of Central Florida, College of Medicine, Orlando, FL 32827, USA
2Orlando VA Medical Center, Orlando, FL 32827, USA

Received 7 April 2015; Accepted 18 May 2015

Academic Editor: Giuseppe Murdaca

Copyright © 2015 Christin Giordano et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Uric acid has been implicated in the pathophysiology of renal disease; however renal clearance makes a causal relationship difficult to prove. We examine the current literature to support a potential role of uric acid in the development of kidney disease and to determine the potential to use uric acid as a marker for future renal decline. After review, we conclude that uric acid is definitively linked to the development of chronic kidney disease and can be a poor prognostic factor for the development of acute renal failure, as well. However, further human research is needed before predictive models utilizing uric acid can be developed and used in the clinical setting.