Circulating MicroRNA-223 Serum Levels Do Not Predict Sepsis or Survival in Patients with Critical Illness

Figure 1

miR-223 serum levels in murine models of septic diseases. (a) Serum was obtained from C57Bl/6j wild-type mice at baseline and 8 hours after injection of 2.5 μg per gram body weight. miR-223 serum levels were measured. The bar graphs represent mean ± SEM from animals per group. (b and c) Serum was obtained from C57Bl/6j wild-type mice at baseline and 8 hours and 24 hours after induction of polymicrobial sepsis by CLP. miR-223 serum levels were measured. The bar graphs represent mean ± SEM; the line graphs display paired pre- and postoperative values for individual animals (). (d) Relative expression of miR-233 in different organs in mice after SHAM or CLP surgery (kidney, spleen, liver, lung, heart, brain, and peripheral blood mononuclear cells (PBMC)) from C57Bl/6j wild-type mice.

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