Circulating MicroRNA-223 Serum Levels Do Not Predict Sepsis or Survival in Patients with Critical Illness

Figure 2

miR-223 serum levels in critically ill patients and healthy controls. (a) Serum concentrations of miR-223 were determined by qPCR in RNA extracts from serum of patients at admission to the intensive care unit (ICU). miR-223 levels were unchanged in critically ill patients () compared with healthy controls (). (b) Serum miR-223 concentrations at admission to the ICU were significantly changed in critically ill patients with high initial Acute Physiology and Chronic Health Evaluation (APACHE) II scores (>10) in comparison to patients with low APACHE-II scores (≤10). (c) Serum miR-223 concentrations at admission to the ICU are unchanged in patients with or without type 2 diabetes mellitus. (d) Serum miR-223 levels at admission to the medical ICU are independent of the presence of obesity in critically ill patients. Box plots are displayed, where the bold line indicates the median per group, the box represents 50% of the values, and the horizontal lines show minimum and maximum values of the calculated nonoutlier values; asterisks and open circles indicate outlier values.

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