Research Article
Circulating MicroRNA-223 Serum Levels Do Not Predict Sepsis or Survival in Patients with Critical Illness
Table 1
Baseline patient characteristics.
| | Parameter | All patients | Nonsepsis | Sepsis | value |
| | Number | 221 | 84 | 137 | n.a. | | Sex (male/female) | 141/80 | 56/28 | 85/52 | n.s. | | Age median (range) [years] | 63 (18–89) | 62 (18–85) | 64 (20–89) | n.s. | | APACHE-II score median (range) | 17 (2–40) | 15 (2–33) | 18.0 (3–40) | n.s | | SAPS2 score median (range) | 42.5 (0–79) | 41 (13–72) | 43 (0–79) | n.s. | | ICU days median (range) | 7 (1–83) | 5 (1–45) | 10 (1–83) | <0.001 | | Death during ICU [%] | 22.2 | 13.1 | 27.7 | <0.05 | | Ventilation [%] | 67.1 | 60.5 | 71.2 | <0.01 | | Body mass index | 26.08 (16.6–86.5) | 26.1 (16.6–53.3) | 26.1 (18.3–86.5) | n.s. | | Creatinine | 1.3 (0–15) | 1.0 (0.3–15.0) | 1.5 (0.0–10.7) | n.s. | | Albumin | 27.0 (15.2–52.2) | 29.2 (0.0–52.2) | 25.8 (0.0–41.0) | n.s. | | WBC median (range) [×10³/μL] | 12.2 (0.1–67.4) | 11.6 (1.8–27.7) | 12.7 (0.1–67.4) | n.s. | | CRP median (range) [mg/dL] | 94.0 (<5–230) | 17 (5–230) | 165 (<5–230) | <0.001 | | Procalcitonin median (range) [μg/L] | 0.7 (0–180.6) | 0.2 (0.1–100.0) | 2.3 (0.0–180.6) | <0.001 | | Interleukin-6 median (range) [pg/mL] | 105 (0–83000) | 63 (4–83000) | 220 (0–28000) | <0.001 | | Tumor necrosis factor median [pg/mL] | 19 (4.9–140) | 16.5 (8.0–100) | 23.5 (4.9–140) | <0.001 | | INR | 1.18 (0–9.2) | 1.16 (0.90–4.32 | 1.18 (0.00–9.2) | n.s. |
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APACHE, Acute Physiology and Chronic Health Evaluation; CRP, C-reactive protein; ICU, intensive care unit; INR, international normalized ratio; SAPS, simplified acute physiology score; WBC, white blood cell count.
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