Dynamic Changes, Cut-Off Points, Sensitivity, and Specificity of Laboratory Data to Differentiate Macrophage Activation Syndrome from Active Disease

Table 4

The results of receiver operating characteristic (ROC) curve analysis for static variables.

Parameter	ROC-AUC	value	Cut-off value	Sensitivity	Specificity	95% confidence interval
WBC1 (×10^3/uL)	0.50	0.96	—	—	—	0.33–0.66
WBC2 (×10^3/uL)	0.77	0.001		70%	86%	0.61–0.93
PMN1 (×10^3/uL)	0.08	0.9	—	—	—	0.34–0.67
PMN2 (×10^3/uL)	0.70	0.02		60%	85%	0.53–0.86
Lymph1 (×10^3/uL)	0.50	0.9	—	—	—	0.33–0.68
Lymph2 (×10^3/uL)	0.83	<0.001		81%	99.94%	0.67–0.99
Hgb1 (g/dL)	0.733	0.004	≤9.2	58%	83%	0.58–0.87
Hgb2 (g/dL)	0.83	<0.001	≤8.9	76%	79%	0.70–0.96
PLT1 (/microliter)	0.76	0.001	≤316500	58%	79%	0.63–0.89
PLT2 (/microliter)	0.96	<0.001	≤204000	94%	99.96%	0.92–1.00
ESR1 (mm/h)	0.41	0.3	—	—	—	0.22–0.60
ESR2 (mm/h)	0.78	0.001	≤54	81%	72%	0.65–0.92
CRP1 (mg/L)	0.71	0.03	≤47.7	61%	69%	0.54–0.85
CRP2 (mg/L)	0.63	0.1	≥103	58%	69%	0.47–0.79
ALT (u/L)	0.85	<0.001	≥38	82%	84%	0.73–0.97
AST (u/L)	0.87	<0.001	≥38.5	82%	78%	0.76–0.98
ALP (U/L)	0.42	0.4	—	—	—	—
ALB (gr/dl)	0.86	0.001	≤3.0	75%	90%	0.72–1.00
BilT (mg/dL)	0.81	0.04	≥0.98	66%	84%	0.59–1.00
BilD (mg/dL)	0.69	0.2	—	—	—	0.42–0.96
Ferritin (ng/mL)	0.81	0.01	≥5277	92%	73%	0.63–0.99
Fibrinogen (mg/dL)	0.69	0.2	—	—	—	0.59–1.00
LDH (Iu/L)	0.80	0.02	≥829	72%	80%	0.63–1.00
BUN (mg/dL)	0.63	0.1	—	—	—	0.46–0.81
Cr (mg/dL)	0.44	0.6	—	—	—	0.25–0.64
Na (meq/L)	0.81	0.005	≤133	70%	75%	0.67–0.95
TG (mg/dL)	0.79	0.1	—	—	—	0.49–1.00
Chol (mg/dL)	0.61	0.6	—	—	—	0.064–1.00
PT	0.74	0.04	≥14.7	61.5%	75%	0.53–0.95
PTT	0.79	0.01	≥39	61	99	0.62–0.97
INR	0.80	0.01	≥1.15	84%	67%	0.62–0.97

ROC-AUC: receiver operating characteristic-area under the curve, MAS: Macrophage Activation Syndrome, WBC: white blood cells, PMN: polymorphonuclear, Lymph: lymphocytes, Hgb: hemoglobin, PLT: platelet, ESR: erythrocyte sedimentation rate, CRP: C-reactive protein, ALT: alanine aminotransferase, AST: aspartate aminotransferase, ALB: albumin, Total Pr: total protein, Bil T: total bilirubin, Bil D: direct bilirubin, LDH: lactate dehydrogenase, BUN: blood urea nitrogen, Cr: creatinine, Na: natrium, TG: triglycerides, Chol: cholesterol, PT: prothrombin time, PTT: partial prothrombin time, and INR: international normalized ratio. The previous laboratory records: WBC1, PMN1, and so forth. The laboratory data at the onset of MAS (MAS group) or active rheumatologic disease (control group): WBC2, PMN2, and so forth. The laboratory data 1 month after discharge from the hospital: WBC3, PMN3, and so forth.