Dynamic Changes, Cut-Off Points, Sensitivity, and Specificity of Laboratory Data to Differentiate Macrophage Activation Syndrome from Active Disease

Table 5

The results of receiver operating characteristic (ROC) curve analysis for dynamic variables.

	ROC-AUC	value	Cut-off value	Sensitivity	Specificity	95% confidence interval
WBC1-WBC2 (×10^3/uL)	0.73	0.004	3570	70%	77%	0.59–0.88
WBC3-WBC2 (×10^3/uL)	0.84	<0.001	195	78%	77%	0.7–0.98
PMN1-PMN2 (×10^3/uL)	0.69	0.02	1938	73%	70%	0.53–0.86
PMN3-PMN2 (×10^3/uL)	0.90	<0.001	−243	84%	86%	0.81–0.99
Lymph1-Lymph2 (×10^3/uL)	0.65	0.09	—	—	—	—
Lymph3-Lymph2 (×10^3/uL)	0.65	0.08	—	—	—	—
Hgb1-Hgb2 (g/dL)	0.72	0.008	0.55	76%	68%	0.58–0.85
Hgb3-Hgb2 (g/dL)	0.52	0.8	—	—	—	—
PLT1-PLT2 (/microliter)	0.78	0.001	30000	82%	60%	0.67–0.90
PL3-PLT2 (/microliter)	0.92	<0.001	97000	78%	90%	0.85–1.00
ESR1-ESR2 (mm/h)	0.69	0.02	9	64%	56%	0.54–0.85
ESR3-ESR2 (mm/h)	0.80	0.002	−4.5	75%	86%	0.63–0.97
CRP1-CRP2 (mg/L)	0.77	0.003	42.5	76%	67%	0.64–0.89
CRP3-CRP2 (mg/L)	0.53	0.5	—	—	—	—

ROC-AUC: receiver operating characteristic-area under the curve, MAS: Macrophage Activation Syndrome, WBC: white blood cells, PMN: polymorphonuclear, Lymph: lymphocytes, Hgb: hemoglobin, PLT: platelet, ESR: erythrocyte sedimentation rate, and CRP: C-reactive protein. The previous laboratory records: WBC1, PMN1, and so forth. The laboratory data at the onset of MAS (MAS group) or active rheumatologic disease (control group): WBC2, PMN2, and so forth. The laboratory data 1 month after discharge from the hospital: WBC3, PMN3, and so forth.