Research Article
Antibodies against C1q Are a Valuable Serological Marker for Identification of Systemic Lupus Erythematosus Patients with Active Lupus Nephritis
Table 3
Association of the presence of laboratory parameters between active and inactive SLE with and without renal involvement (mean ± SD) (
).
| | Group | Activity of SLE () | SLE with renal involvement () | | Active SLE () | Inactive SLE () | value | LN () | Non-LN () | value |
| | ACL Ab (+) number (%) | 7/51 (13.7) | 5/44 (11.4) | NA | 4/35 (11.4) | 8/60 (13.3) | NA | | Anti-C1q (+) number (%) | 40/51 (78.4) | 10/44 (22.7) | NA | 30/35 (85.7) | 20/60 (33.3) | NA | | Anti-dsDNA (+) number (%) | 50/51 (98.0) | 28/44 (63.6) | NA | 34/35 (97.1) | 44/60 (73.3) | NA | | ANA (+) number (%) | 51/51 (100) | 44/44 (100) | NA | 35/35 (100) | 60/60 (100) | NA | | Anti-Rib-P (+) number (%) | 4/51 (7.8) | 1/44 (2.3) | NA | 3/35 (8.6) | 2/60 (3.3) | NA | | Anti-Smith (Sm) (+) number (%) | 23/51 (45.1) | 10/44 (22.7) | NA | 19/35 (54.3) | 14/60 (23.3) | NA | | Anti-SSA Ab (+) number (%) | 15/51 (29.4) | 8/44 (18.2) | NA | 12/35 (34.3) | 11/60 (18.3) | NA | | Anti-SSB Ab (+) number (%) | 4/51 (7.8) | 4/44 (2.3) | NA | 4/35 (11.4) | 4/60 (6.7) | NA | | pANCA (+) number (%) | 16/51 (31.4) | 3/44 (6.8) | NA | 8/35 (22.9) | 11/60 (18.3) | NA | | C3 (μg/mL) | 0.55 ± 0.16 | 0.97 ± 0.16 | 0.047 | 0.47 ± 0.22 | 1.09 ± 0.16 | 0.031 | | C4 (μg/mL) | 0.14 ± 0.05 | 0.17 ± 0.07 | 0.142 | 0.12 ± 0.04 | 0.19 ± 0.10 | 0.045 | | Anti-C1q (AU/mL) | 60.9 ± 11.6 | 8.3 ± 3.5 | 0.000 | 68.1 ± 14.6 | 14.1 ± 3.8 | 0.000 | | Anti-dsNDA (IU/mL) | 72.45 ± 23.60 | 11.67 ± 6.89 | 0.000 | 78.97 ± 19.74 | 10.56 ± 4.89 | 0.000 | | Hemoglobin (μg/mL) | 24.6 ± 11.7 | 12.7 ± 0.89 | 0.008 | 25.7 ± 9.8 | 11.2 ± 1.92 | 0.004 | | Urine protein (g/24 hours) | 1.19 ± 0.61 | 0.11 ± 0.04 | 0.003 | 1.31 ± 0.77 | 0.09 ± 0.07 | 0.000 |
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Ab: antibody; ACL: anti-cardiolipin; ANA: anti-nuclear antibody; LN: lupus nephritis; pANCA: perinuclear anti-neutrophil cytoplasmic antibody; Rib-P: ribosomal P-proteins; RNP: ribonucleoprotein; SSA: Sjögren’s syndrome A; SSB: anti-Sjögren’s syndrome B.
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