Site-Specific Secretome Map Evidences VSMC-Related Markers of Coronary Atherosclerosis Grade and Extent in the Hypercholesterolemic Swine

Table 2

Differential protein expression between HF RCA and CTRL cases.

Localization	Gene name	Protein name	Coronary HF/CTRL	value	SecretomeP	Plasma	Role in atherogenesis
Cellular	G3P	Glyceraldehyde-3-phosphate dehydrogenase	Up	0.05	√	√	Glucose metabolism
	CATD	Cathepsin D	Up	0.009	√	√	Macrophage phagocytosis, lipid efflux [40, 41]
	DESM	Desmin	Up	0.04	√		Focal adhesion [29]
	VIME	Vimentin	Up	0.02	√		Focal adhesion [29]
	CPNS1	Calpain	Up	0.05	√		Calcium binding, proatherogenic [42]
	ICAL	Calpastatin	Up	0.05	Not predicted		Calcium binding, calpain inhibitor
	MOES	Moesin	Up	0.005	√		Focal adhesion [43]
	CH3L1	Chitinase-3-like protein 1	Up	0.004	√	√	Adhesion and migration [37]
	S10A6	Protein S100-A6	Up	0.05	√	√	RAGE ligand and marker of MI [44]
	LMNA	Prelamin-A/C	Up	0.03	Not predicted		Oxidative stress, vascular aging [45]
	GPX1	Glutathione peroxidase 1	Up	0.05	√		Oxidative stress
Extracellular matrix	PGS1	Biglycan	Up	0.04	√	√	Lipoprotein retention [46]
	HPLN1	Hyaluronan and proteoglycan link protein 1	Down	0.000033	√	√	Plaque stability, atheroprotection [47]
	OSTP	Osteopontin	Up	0.04	√	√	Secondary carotid events marker [39]
	APOA1	Apolipoprotein A-I	Up	0.01	√	√	HDL constituent, atheroprotection [48]
	APOE	Apolipoprotein E	Up	0.0007	√	√	Atheroprotection [49]
	APOA4	Apolipoprotein A-IV	Down	0.03	√	√	Antioxidative, atheroprotection [50]

First column: biological localization of proteins. Second column: gene name. Third column: protein names reported according to SwissProt 2013 database. Sixth column: secretion potential as predicted according to SecretomeP software. Seventh column: presence in plasma, according to Human Protein Reference database (http://www.hprd.org). Eighth column: roles in atherogenesis, as suggested in the literature.