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Disease Markers
Volume 2015 (2015), Article ID 472750, 9 pages
http://dx.doi.org/10.1155/2015/472750
Research Article

Hemostatic Parameters according to Renal Function and Time after Transplantation in Brazilian Renal Transplanted Patients

1Departamento de Analises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, 31270901 Belo Horizonte, MG, Brazil
2Departamento de Ciências da Saúde, Faculdade de Farmácia, Universidade Federal de São João del-Rei, 35501296 Divinópolis, MG, Brazil
3Departamento de Pediatria, Faculdade de Medicina, Universidade Federal de Minas Gerais, 30130100 Belo Horizonte, MG, Brazil

Received 24 March 2015; Revised 30 May 2015; Accepted 16 June 2015

Academic Editor: Shih-Ping Hsu

Copyright © 2015 Ana Paula Lucas Mota et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Kidney transplantation is the key for patients with end-stage renal disease, improving quality of life and longer survival. However, kidney transplant triggers an intense inflammatory response and alters the hemostatic system, but the pathophysiological mechanisms of these changes are not completely understood. The aim of this cross-sectional cohort study was to investigate hemostatic biomarkers in Brazilian renal transplanted patients according to renal function and time after transplantation. A total of 159 renal transplanted patients were enrolled and D-Dimer (D-Di), Thrombomodulin (TM), von Willebrand Factor (VWF), and ADAMTS13 plasma levels were assessed by ELISA. An increase of D-Di was observed in patients with higher levels of creatinine. ADAMTS13 levels were associated with creatinine plasma levels and D-Di levels with Glomerular Filtration Rate. These results suggested that D-Di and ADAMTS13 can be promising markers to estimate renal function. ADAMTS13 should be investigated throughout the posttransplant time to clarify the participation of this enzyme in glomerular filtration and acceptance or rejection of the graft in Brazilian transplanted patients.