Prognostic Value of MicroRNA-182 in Cancers: A Meta-Analysis

Table 1

Characteristics of the studies included in the meta-analysis.

Author	Year	Country	Type	Sample	Number	Method	Cutoff	Survival	HR	Max follow-up (months)
Chen	2014	China	Pancreatic	Plasma	109	qRT-PCR	Youden index	OS, DFS	R	60
Rapti	2014	Greece	Colorectal	Frozen tissue	105 OS	qRT-PCR	65%	OS, DFS	R	120
					92 DFS
Wang	2014	China	Colorectal	FFPE	138	ISH	Score = 3 (0–7)	OS	R	96
Li	2014	China	Pancreatic	Primary tissue	38	qRT-PCR	Matched nontumor tissue	OS	SC	36
Pignot	2013	France	MIBC	Frozen tissue	72	qRT-PCR	NR	OS, RFS	SC	65
Kunder	2013	India	Group 3 and 4 medulloblastomas	Frozen tissue + FFPE	37	qRT-PCR	Log2 (relative quantity)	OS	R	60
Liu	2013	China	Colorectal	Frozen tissue	148	qRT-PCR	Median	OS	R	89
McMillen	2012	USA	Grade III or IV ovarian	FFPE	107	ISH	Score > 1.5 (0–3)	OS	R	82
Zhu	2011	China	NSCLC	Frozen tissue	70	qRT-PCR	Median	OS	R	25
Jiang	2010	China	Glioma	PE	119	qRT-PCR	Median	OS	(RR) R	80
Stenvold	2014	Norway	NSCLC	FFPE	305	ISH	Score > 0 (0–3)	DSS	R	234
Lei	2014	China	Breast	Fresh tumor specimens	38	qRT-PCR	Median	RFS	SC	50
Wang	2012	China	HCC	Frozen tissue	86	qRT-PCR	Median	DFS	SC	56
Schaefer	2010	Germany	Prostate	Frozen tissue	75	qRT-PCR	Median	RFI	R	93
Casanova-Salas^a	2014	Spain	Prostate	FFPE	272	qRT-PCR	Low/medium/high	PFS	SC	189
Rodríguez-González^a	2011	Netherlands	ER+ breast	Tissue	246	qRT-PCR	Divided into quarters	PFS	SC	24
Hirata^b	2012	USA	Bladder	FFPE	18	qRT-PCR	Median	OS	SC	120
Hirata^b	2013	USA	Prostate	FFPE	52	qRT-PCR	Median	OS	SC	100

DFS: disease-free survival, DSS: disease-specific survival, ER: estrogen receptor, FFPE: formalin-fixed paraffin embedded tissues, HCC: hepatocellular carcinoma, HR: hazard ratio, ISH: in situ hybridization, MIBC: muscle-invasive bladder cancer, NR: not reported, NSCLC: nonsmall lung cancer, OS: overall survival, PFS: progression-free survival, R: reported, RFI: recurrence-free interval, RFS: relapse-free survival, RR: relative risk, and SC: survival curve.
^aExcluded due to nondichotomy; ^b95% CIs of HR extracted from the Kaplan-Meier survival curves were not accurate (HR > 50, 95% CI: 0–∞).