Circulating Soluble Neuropilin-1 in Patients with Early Cervical Cancer and Cervical Intraepithelial Neoplasia Can Be Used as a Valuable Diagnostic Biomarker

Table 1

Expression of NRP-1 protein in 74 cervical tissues.

Factor	Classification		NRP-1 positive (%)	^*
Age	>40 y	33	23 (69.70)	>0.05
	40 y	7	6 (85.71)
Clinical stage	Controls^*	20	4 (20.0)	<0.01
	CIN	14	10 (71.43)
	LECC	25	18 (72.0)
	LACC	15	11 (73.33)
Nodal metastasis^**	Absent	28	21 (75.0)	>0.05
	Present	12	8 (66.67)
Pathological grade	HG1	7	5 (71.43)	0.037
	HG2	25	21 (84.0)
	HG3	8	3 (37.5)
Pathological types	SCC	31	22 (70.97)	>0.05
	ACC	9	7 (77.77)

SCC: squamous cancer, ACC: adenocarcinoma, CIN: cervical intraepithelial neoplasia, LECC: local early cervical cancer, stage I a1 to I b1, and LACC: local advanced cervical cancer, stage I b2 to IIa. ^*The occurrence of NRP-1 protein of this group was much lower than that of the other 3 groups. ^**Pelvic lymphatic nodes involved only.