Predictive Performance of a Seven-Plex Antibody Array in Prenatal Screening for Down Syndrome

Table 3

Model predicted DS detection rate (and 95% CI) for 5% False Positive Rate and corresponding Area under the Curve, for models based on prior risk and several marker combinations. DR, detection rate; CI, confidence interval; AUC, Area under the Curve.

Model	DR (%)	DR 95% CI	AUC
Prior risk	27	(19–36)	0.741
Prior risk + PAPP-A + fβ-hCG (4PL)	58	(49–66)	0.873
Prior risk + PAPP-A + fβ-hCG (scaled)	58	(49–67)	0.870
Prior risk + PAPP-A + fβ-hCG (AutoDelfia)	59	(51–68)	0.880
Prior risk + AFP	28	(19–39)	0.748
Prior risk + PAPP-A + fβ-hCG (scaled) + AFP	59	(49–68)	0.869
Prior risk + ANGPTL3	26	(16–36)	0.732
Prior risk + PAPP-A + fβ-hCG (scaled) + ANGPTL3	58	(48–66)	0.869
Prior risk + EGF	25	(17–34)	0.739
Prior risk + PAPP-A + fβ-hCG (scaled) + EGF	59	(50–67)	0.870
Prior risk + IGF2	28	(18–38)	0.742
Prior risk + PAPP-A + fβ-hCG (scaled) + IGF2	58	(49–66)	0.870
Prior risk + SOD1	19	(10–31)	0.736
Prior risk + PAPP-A + fβ-hCG (scaled) + SOD1	58	(49–66)	0.870
Prior risk + IgG	19	(9–31)	0.739
Prior risk + PAPP-A + fβ-hCG (scaled) + IgG	57	(49–66)	0.872