Disease Markers / 2015 / Article / Tab 1 / Review Article
Roles of NOTCH1 as a Therapeutic Target and a Biomarker for Lung Cancer: Controversies and Perspectives Table 1 Key references for the role of NOTCH1 in lung cancer.
References Subtype Key findings Potential role of NOTCH1 [10 , 11 ] SCLC NOTCH1 inhibited cell proliferation and neuroendocrine marker expression. Tumor suppressive [12 , 13 ] SCLC NOTCH1 induced growth inhibition and cell cycle arrest. Tumor suppressive [30 ] SCLC NOTCH1 inhibited EMT and invasion. Tumor suppressive [14 ] NSCLC Knockdown of NOTCH1 inhibited cell growth; NICD1 promoted cell growth in the presence of EGF. Oncogenic [15 , 16 ] NSCLC Hypoxia-induced HIF1 Oncogenic [23 –27 ] NSCLC Inactivation of NOTCH1 or its mediators in mouse models of NSCLC abrogated tumorigenesis. Oncogenic [31 ] NSCLC Inactivation of the NOTCH ligand Jagged2 inhibited EMT and metastasis. Oncogenic [32 ] NSCLC Galectin-1 increased Jagged2 and NOTCH1 to promote metastasis. Oncogenic [33 ] NSCLC ADAM10 activated NOTCH1 to promote invasion. Oncogenic [34 ] NSCLC NICD1 induced EMT and destroyed adherens junctions. Oncogenic [35 ] NSCLC NICD1 transcriptionally activated SOX9 to drive EMT and invasion. Oncogenic [36 –39 ] NSCLC Higher NOTCH1 correlated with disease progression, metastasis, and poorer prognosis. Oncogenic [40 ] NSCLC Gain-of-function NOTCH1 mutations are identified in a subset of patients; activated NOTCH1 activity correlated with poorer survival of NSCLC patients without p53 mutations. Oncogenic [17 ] NSCLC NICD1 inhibited cell and xenograft tumor growth. Tumor suppressive [18 ] NSCLC NOTCH1 mediated Z-Isochaihulactone-induced growth inhibition. Tumor suppressive [19 ] NSCLC Endothelial DLL4 activated tumor cell NOTCH1 to inhibit growth. Tumor suppressive [41 ] NSCLC NOTCH1 expression negatively correlated with metastasis and predicted better survival. Tumor suppressive [42 ] NSCLC NICD1 was only detected in a small proportion of patient tissues and had no prognostic value.
