Disease Markers / 2015 / Article / Tab 1

Review Article

Roles of NOTCH1 as a Therapeutic Target and a Biomarker for Lung Cancer: Controversies and Perspectives

Table 1

Key references for the role of NOTCH1 in lung cancer.

ReferencesSubtypeKey findingsPotential role of NOTCH1

[10, 11]SCLCNOTCH1 inhibited cell proliferation and neuroendocrine marker expression.Tumor suppressive

[12, 13]SCLCNOTCH1 induced growth inhibition and cell cycle arrest.Tumor suppressive

[30]SCLCNOTCH1 inhibited EMT and invasion.Tumor suppressive

[14]NSCLCKnockdown of NOTCH1 inhibited cell growth; NICD1 promoted cell growth in the presence of EGF.Oncogenic

[15, 16]NSCLCHypoxia-induced HIF1 activated NOTCH1 to promote cell growth; the -secretase inhibitor MRK-003 induced cell apoptosis under the condition of hypoxia.Oncogenic

[2327]NSCLCInactivation of NOTCH1 or its mediators in mouse models of NSCLC abrogated tumorigenesis.Oncogenic

[31]NSCLCInactivation of the NOTCH ligand Jagged2 inhibited EMT and metastasis.Oncogenic

[32]NSCLCGalectin-1 increased Jagged2 and NOTCH1 to promote metastasis.Oncogenic

[33]NSCLCADAM10 activated NOTCH1 to promote invasion.Oncogenic

[34]NSCLCNICD1 induced EMT and destroyed adherens junctions.Oncogenic

[35]NSCLCNICD1 transcriptionally activated SOX9 to drive EMT and invasion.Oncogenic

[3639]NSCLCHigher NOTCH1 correlated with disease progression, metastasis, and poorer prognosis.Oncogenic

[40]NSCLCGain-of-function NOTCH1 mutations are identified in a subset of patients; activated NOTCH1 activity correlated with poorer survival of NSCLC patients without p53 mutations.Oncogenic

[17]NSCLCNICD1 inhibited cell and xenograft tumor growth.Tumor suppressive

[18]NSCLCNOTCH1 mediated Z-Isochaihulactone-induced growth inhibition.Tumor suppressive

[19]NSCLCEndothelial DLL4 activated tumor cell NOTCH1 to inhibit growth. Tumor suppressive

[41]NSCLCNOTCH1 expression negatively correlated with metastasis and predicted better survival.Tumor suppressive

[42]NSCLCNICD1 was only detected in a small proportion of patient tissues and had no prognostic value.