Research Article
A Genetic Variant in miRNA-219-1 Is Associated with Risk of Esophageal Squamous Cell Carcinoma in Chinese Kazakhs
Table 3
Logistic regression analyses of associations between miR-219-1 rs107822G > A and rs213210T > C polymorphisms and risk of Kazakh ESCC.
| | Genotype | Cases [ (%)] | Controls [ (%)] |
Crude OR
(95% CI) | value |
Adjusted OR
(95% CI) | value | | () | () |
| | miR-219-1 (rs107822G > A) | | | | | | | | GG | 65 (32.8) | 67 (24.6) | 1 | | 1 | | | GA | 98 (49.5) | 104 (38.2) | 0.971 (0.626–1.506) | 0.897 | 0.976 (0.626–1.522) | 0.914 | | AA | 35 (17.7) | 101 (37.2) | 0.357 (0.214–0.597) | 8.662 × 10−5 | 0.365 (0.217–0.614) | 1.429 × 10−4 | | GG vs. GA vs. AA | | | | | | 2.606 × 10−5 | | GA+AA | 133 (67.2) | 205 (75.4) | 0.6669 (0.446–1.003) | 0.052 | 0.677 (0.449–1.021) | 0.063 | | GG+GA | 163 (82.3) | 171 (62.8) | 1 | | 1 | | | AA | 35 (17.7) | 101 (37.2) | 0.364 (0.234–0.565) | 6.646 × 10−6 | 0.371 (0.238–0.577) | 1.134 × 10−5 | | G allele | 228 (57.6) | 238 (43.8) | 1 | | | | | A allele | 168 (42.4) | 306 (56.2) | 0.573 (0.441–0.744) | 2.837 × 10−5 | | | | miR-219-1 (rs213210T > C) | | | | | | | | TT | 161 (65.7) | 195 (68.4) | 1 | | 1 | | | CT | 78 (31.8) | 83 (29.2) | 1.138 (0.784–1.653) | 0.496 | 1.172 (0.805–1.709) | 0.408 | | CC | 6 (2.5) | 7 (2.4) | 1.038 (0.342–3.151) | 0.947 | 1.057 (0.346–3.231) | 0.923 | | TT vs. CT vs. CC | | | | | | 0.793 | | CT+CC | 84 (34.3) | 90 (31.6) | 1.130 (0.786–1.626) | 0.508 | 1.164 (0.806–1.680) | 0.419 | | TT+TC | 259 (97.5) | 278 (97.6) | 1 | | 1 | | | CC | 6 (2.5) | 7 (2.4) | 0.997 (0.331–3.007) | 0.996 | 1.003 (0.330–3.044) | 0.996 | | T allele | 400 (81.6) | 473 (83) | 1 | | | | | C allele | 90 (18.4) | 97 (17) | 1.097 (0.800–1.505) | 0.565 | | |
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Logistic regression adjusted for age and sex.
P values under 0.05 were indicated in bold font.
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