The Affymetrix DMET Plus Platform Reveals Unique Distribution of ADME-Related Variants in Ethnic Arabs

Table 1

Distribution of some of the common CYP450 variants.

Group	Total	Undetected	<0.01	>0.01
All	437	222 (0.51)	55 (0.125)	160 (0.366)
CYP1A	30	20 (0.666)	1 (0.033)	9 (0.3)
CYP1B	20	16 (0.80)	1 (0.5)	3 (0.15)
CYP2A	34	20 (0.58)	3 (0.09)	11 (0.32)
CYP2B	24	10 (0.42)	2 (0.08)	12 (0.5)
CYP2C	53	26 (0.49)	14 (0.26)	13 (0.25)
CYP2D	30	14 (0.47)	4 (0.13)	12 (0.4)
CYP2E	10	2 (0.20)	3 (0.3)	5 (0.5)
CYP2F	5	0 (0.0)	2 (0.4)	3 (0.6)
CYP2J	9	8 (0.89)	0 (0.0)	1 (0.11)
CYP2S	4	1 (0.25)	1 (0.25)	2 (0.5)
CYP3A	53	36 (0.68)	3 (0.06)	14 (0.26)
CYP4A	4	1 (0.25)	1 (0.25)	2 (0.5)
CYP4B	7	0 (0.0)	2 (0.28)	5 (0.72)
CYP4F	35	12 (0.34)	2 (0.06)	21 (0.6)
CYP4Z	4	1 (0.25)	0 (0.0)	3 (0.75)
CYP7A	7	1 (0.142)	1 (0.142)	5 (0.714)
CYP7B	4	0 (0.0)	1 (0.25)	3 (0.75)
CYP8B	7	0 (0.0)	4 (0.571)	3 (0.428)
CYP11A	7	7 (1.00)	0 (0.0)	0 (0.0)
CYP11B	24	15 (0.63)	0 (0.0)	9 (0.36)
CYP17A	6	3 (0.50)	0 (0.0)	3 (0.50)
CYP19A	11	6 (0.54)	0 (0.0)	5 (0.46)
CYP20A	5	2 (0.40)	0 (0.0)	3 (0.60)
CYP21A	3	3 (1.00)	0 (0.0)	0 (0.0)
CYP24A	8	4 (0.50)	0 (0.0)	4 (0.50)
CYP26A	5	0 (0.0)	2 (0.4)	3 (0.6)
CYP26C	1	0 (0.0)	1 (1.0)	0 (0.0)
CYP27A	6	4 (0.67)	2 (0.33)	0 (0.0)
CYP27B	9	5 (0.56)	2 (0.22)	2 (0.22)
CYP39A	4	1 (0.25)	1 (1.25)	2 (0.50)
CYP46A	1	1 (1.00)	0 (0.0)	0 (0.0)
CYP51A	7	3 (0.43)	2 (0.285)	2 (0.285)

The table displays the relative minor allele frequency distribution of the CYP450 variants determined by DMET Plus chip in 600 individuals.