High Serum Level of β2-Microglobulin in Late Posttransplant Period Predicts Subsequent Decline in Kidney Allograft Function: A Preliminary Study

Table 3

Significant predictors of eGFR decline by ≥25% after one and two years of follow-up.

Predictive variables	Univariate logistic regression			Multivariate logistic regression
	OR	CI	value	OR	CI	value
eGFR decline by ≥25% after 1 year of follow-up,
Proteinuria/creatinine	1.03	1.00–1.07	0.038	1.03	0.99–1.07	0.158
Serum β2MG	1.51	1.10–2.07	0.010	1.54	1.05–2.26	0.025
Previous acute rejection	4.82	1.12–20.84	0.032	2.24	0.36–13.85	0.378
eGFR decline by ≥25% after 2 years of follow-up,
Serum β2MG	1.36	1.06–1.76	0.016	1.41	1.06–1.87	0.016
Time after transplantation	1.02	1.00–1.03	0.006	1.02	1.00–1.03	0.006

β2MG: β2-microglobulin; eGFR: estimated glomerular filtration rate; OR: odds ratio; CI: 95% confidence interval; : number of patients with certain decline in eGFR; only variables that significantly influenced the eGFR decline in univariate analysis are included.