Disease Markers / 2015 / Article / Tab 2

Research Article

Prognostic Value of High CXCR4 Expression in Renal Cell Carcinoma: A System Review and Meta-Analysis

Table 2

Clinical data of studies included in meta-analysis.

First author/
publication year
SamplesGender (M/F)Age (years)Pathological patternFuhrman stageImmunohistochemistryEvaluation of expression level (CXCR4)Low versus high (CXCR4)
Histologic originAntibody source Dilution

An, 2014 [2]TS
VS
125
100
84/41
65/35
57.6 ± 12.7
60.5 ± 11.5
ccRCC
ccRCC
I-II/III-IV; 75/50
I-II/III-IV; 62/38
Tumor sectionsMouse; R&D Systems, USA1 : 400Five-staged score (0, 1, 2, 3, and 4)High (scores 0, 1, and 2) versus low (scores 3 and 4)

Li, 2013 [20]10469/3564.5 (34–86)ccRCCI-II/III-IV; 63/41Tissue sectionsRabbit; Abcam, UKNARange of positive cells: high; moderate 25–85%; low <25%; and absence = 0% ≥85% versus <85%

D’Alterio, 2012 [19]6245/1755 (31–82)mRCCFuhrman grading:
I-II/III-IV; 12/50
Histologic sectionsMouse; R&D Systems, USA1 : 1000The rate of stained (positive) tumor cells: 0–5% low, >5–20% intermediate, and >20% highNegative/low versus
Mediate versus high

Wang, 2012 [21]9760/37≤60/>60; 63/34ccRCC and othersFuhrman grading:
I-II/III-IV; 67/30
Tissue sectionsMouse; R&D Systems, USANAThe 25th percentile value of the average percentage of positive tumor cellsHigh (≥30%) versus low (<30%)

Li, 2011 [11]11778/39≥60/<60; 54/63ccRCC and LARCCFuhrman grading:
I–III/IV; 96/21
Tissue sectionsMouse; R&D Systems, USA1 : 100Conventional four-tiered semiquantitative scoring system: scores 0–3 for negative, weak, moderate, and strong stainingPositive (+) versus negative (−)

D’Alterio, 2010 [17, 18]223121/102≥70/<70; 99/124RCC (chromophobe, conventional, papillary, bellini and other)Fuhrman grading:
I–III/IV; 168/53
Histologic sectionsMouse; R&D Systems, USA1 : 2000The rate of positive tumor cells in 10 high power field (400x)/slide: 0–5% low, >5–20% intermediate, and >20% high 20%> versus >20%

D’Alterio, 2010 [17, 18]240139/10161 (26–84)RCC (chromophobe, papillary, clear cell and other)Fuhrman grading:
I-II/III-IV; 163/58
Tissue sectionsMouse; R&D Systems, USA1 : 2000The rate of positive tumor cells in 10 high power field (400x)/slide: 0–5% low, >5–20% intermediate, and >20% high20%> versus >20%

TS: training set, VS: validation set, M/F: male/female, ccRCC: clear cell RCC, mRCC: metastasis RCC, and LARCC: locally advanced RCC.

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.