Prognostic Value of High CXCR4 Expression in Renal Cell Carcinoma: A System Review and Meta-Analysis

Table 3

Subgroup analysis based on characteristics of various studies.

Variables	T/P	Overall survival
		HR (95% CI)	-squared (%)	Model	-He	value	value
Overall	5/605	2.77 (1.80, 4.27)	51.7	Random effect	0.066	4.61	<0.001
Ethnicity
Asian	3/439	3.78 (2.47, 5.78)	0.0	Fixed effect	0.60	6.13	<0.001
Non-Asian	2/166	1.68 (1.14, 2.48)	0.0	Fixed effect	0.35	2.63	0.009
Fuhrman grades III-IV (%)
>70	1/62	1.48 (0.93, 2.37)	NA	NA	NA	1.64	0.102
≤70	4/543	3.26 (2.27, 4.67)	0.0	Fixed effect	0.471	6.41	<0.001
Median follow-up (months)
>60	2/329	2.70 (1.73, 4.21)	0.0	Fixed effect	0.727	4.39	<0.001
≤60	3/276	3.10 (1.24, 7.80)	78.6	Random effect	0.009	2.41	0.016

T/P: number of trials/number of patients, -He: value of heterogeneity.