Table of Contents Author Guidelines Submit a Manuscript
Letter to the Editor
Research Article
Disease Markers
Volume 2015, Article ID 583738, 2 pages
http://dx.doi.org/10.1155/2015/583738
Letter to the Editor

Response to: Comment on “Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio: Novel Markers for Diagnosis and Prognosis in Patients with Idiopathic Sudden Sensorineural Hearing Loss”

1Department of Otorhinolaryngology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea
2Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Republic of Korea

Received 11 September 2014; Accepted 11 September 2014

Academic Editor: Yi-Chia Huang

Copyright © 2015 Young Joon Seo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We are very pleased to get those comments on our paper, because those things were important considerations we thought in these results. But we have to comment against those questions.(1)The WBC counts could reflect an acute inflammation [1]. We excluded patients not only by WBC counts. We excluded the patients with fever, physical exam, and medical history (because the WBC count was performed at the initial visit, we could discriminate acute inflammations with physical exams). We excluded patients over 11000/u (because 10000 is upper limit in our hospital, but 10% error could be possible) [2]. So we add 1000/u to the normal value. We think it could be acceptable universally. And the findings of the increasing in the WBC and neutrophil are important findings, though they had no evidence of acute inflammations. The author misunderstood the subject of this study.(2)DM is so important risk factor for sudden SNHL. Glucose levels affect vascular insufficiency to make sudden SNHL. We did already consider that in the discussion. This study was retrospectively performed. We could not control the case group. So we mentioned these limitations in the discussion [3, 4]. “Although glucose between the patients group and the control group was significantly different, because we could not control the sugar test with fasting glucose test for all patients and control group, we cannot be sure the value as the important risk factor.”(3)Before binary logistic regression analysis, univariate logistic regression analysis is important. But WBC includes neutrophil, lymphocyte, and monocyte [5]. Changes of neutrophil automatically affect lymphocyte. We did univariate logistic regression analysis, but in this statistics, binary logistic regression would be preferred.(4)And we did not want to point out the cut-off value. We need to study more about that in the future. In conclusion, the author considered so important points. But they did not consider this study was a retrospective study and we already thought about those things. So we want to reconsider for the publication.

Conflict of Interests

The authors declare that there is no conflict of interests regarding the publication of this paper.

References

  1. M. Hoffman, A. Blum, R. Baruch, E. Kaplan, and M. Benjamin, “Leukocytes and coronary heart disease,” Atherosclerosis, vol. 172, no. 1, pp. 1–6, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. F. Imtiaz, K. Shafique, S. Mirza, Z. Ayoob, P. Vart, and S. Rao, “Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population,” International Archives of Medicine, vol. 5, no. 1, article 2, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. Y. J. Seo, J. H. Jeong, J. Y. Choi, and I. S. Moon, “Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio: novel markers for diagnosis and prognosis in patients with idiopathic sudden sensorineural hearing loss,” Disease Markers, vol. 2014, Article ID 702807, 6 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Papa, M. Emdin, C. Passino, C. Michelassi, D. Battaglia, and F. Cocci, “Predictive value of elevated neutrophil-lymphocyte ratio on cardiac mortality in patients with stable coronary artery disease,” Clinica Chimica Acta, vol. 395, no. 1-2, pp. 27–31, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. J. C. Stoltzfus, “Logistic regression: a brief primer,” Academic Emergency Medicine, vol. 18, no. 10, pp. 1099–1104, 2011. View at Publisher · View at Google Scholar · View at Scopus