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Disease Markers
Volume 2015, Article ID 614145, 9 pages
http://dx.doi.org/10.1155/2015/614145
Review Article

Copeptin Testing in Acute Myocardial Infarction: Ready for Routine Use?

Department of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria

Received 6 October 2014; Accepted 12 January 2015

Academic Editor: Serge Masson

Copyright © 2015 Sebastian Johannes Reinstadler et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. Thygesen, J. S. Alpert, A. S. Jaffe et al., “Third universal definition of myocardial infarction,” European Heart Journal, vol. 33, no. 20, pp. 2551–2567, 2012. View at Google Scholar
  2. T. Reichlin, W. Hochholzer, S. Bassetti et al., “Early diagnosis of myocardial infarction with sensitive cardiac troponin assays,” New England Journal of Medicine, vol. 361, no. 9, pp. 858–867, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. T. Keller, T. Zeller, D. Peetz et al., “Sensitive troponin I assay in early diagnosis of acute myocardial infarction,” The New England Journal of Medicine, vol. 361, no. 9, pp. 868–877, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Mair, “High-sensitivity cardiac troponins in everyday clinical practice,” World Journal of Cardiology, vol. 6, no. 4, pp. 175–182, 2014. View at Publisher · View at Google Scholar
  5. C. W. Hamm, J.-P. Bassand, S. Agewall et al., “ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: the Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC),” European Heart Journal, vol. 32, no. 23, pp. 2999–3054, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. C. Mueller, “Biomarkers and acute coronary syndromes: an update,” European Heart Journal, vol. 35, no. 9, pp. 552–556, 2014. View at Publisher · View at Google Scholar
  7. S. K. James, B. Lindahl, A. Siegbahn et al., “N-terminal pro-brain natriuretic peptide and other risk markers for the separate prediction of mortality and subsequent myocardial infarction in patients with unstable coronary artery disease: a global utilization of strategies to open occluded arteries (GUSTO)-IV substudy,” Circulation, vol. 108, no. 3, pp. 275–281, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. C. W. Hamm, B. U. Goldmann, C. Heeschen, G. Kreymann, J. Berger, and T. Meinertz, “Emergency room triage of patients with acute chest pain by means of rapid testing for cardiac troponin T or troponin I,” The New England Journal of Medicine, vol. 337, no. 23, pp. 1648–1653, 1997. View at Publisher · View at Google Scholar · View at Scopus
  9. G. Klug, A. Mayr, J. Mair et al., “Role of biomarkers in assessment of early infarct size after successful p-PCI for STEMI,” Clinical Research in Cardiology, vol. 100, no. 6, pp. 501–510, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Furtner, T. Ploner, A. Hammerer-Lercher, R. Pechlaner, and J. Mair, “The high-sensitivity cardiac troponin T assay is superior to its previous assay generation for prediction of 90-day clinical outcome in ischemic stroke,” Clinical Chemistry and Laboratory Medicine, vol. 50, no. 11, pp. 2027–2029, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. G. E. Cramer, M. A. Brouwer, H. L. Vader et al., “Highly sensitive cardiac troponin T and long-term mortality in a population of community-derived perimenopausal women: nested case-control study,” Heart, vol. 99, no. 8, pp. 528–533, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. T. Kubo, H. Kitaoka, S. Yamanaka et al., “Significance of high-sensitivity cardiac troponin T in hypertrophic cardiomyopathy,” Journal of the American College of Cardiology, vol. 62, no. 14, pp. 1252–1259, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. A. M. C. Neukamm, A. D. Høiseth, T.-A. Hagve, V. Søyseth, and T. Omland, “High-sensitivity cardiac troponin T levels are increased in stable COPD,” Heart, vol. 99, no. 6, pp. 382–387, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Dispenzieri, M. A. Gertz, S. K. Kumar et al., “High sensitivity cardiac troponin T in patients with immunoglobulin light chain amyloidosis,” Heart, vol. 100, no. 5, pp. 383–388, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Mayr, J. Mair, M. Schocke et al., “Predictive value of NT-pro BNP after acute myocardial infarction: relation with acute and chronic infarct size and myocardial function,” International Journal of Cardiology, vol. 147, no. 1, pp. 118–123, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. K. Thygesen, J. Mair, C. Mueller et al., “Recommendations for the use of natriuretic peptides in acute cardiac care: a position statement from the Study Group on Biomarkers in Cardiology of the ESC Working Group on Acute Cardiac Care,” European Heart Journal, vol. 33, no. 16, pp. 2001–2006, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. D. A. Morrow, N. Rifai, E. M. Antman et al., “C-reactive protein is a potent predictor of mortality independently of and in combination with troponin T in acute coronary syndromes: a TIMI 11A substudy,” Journal of the American College of Cardiology, vol. 31, no. 7, pp. 1460–1465, 1998. View at Publisher · View at Google Scholar · View at Scopus
  18. K. Thygesen, J. Mair, E. Giannitsis et al., “How to use high-sensitivity cardiac troponins in acute cardiac care,” European Heart Journal, vol. 33, no. 18, pp. 2252–2257, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Mayr, G. Klug, M. Schocke et al., “Late microvascular obstruction after acute myocardial infarction: relation with cardiac and inflammatory markers,” International Journal of Cardiology, vol. 157, no. 3, pp. 391–396, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. R. G. O'Malley, M. P. Bonaca, B. M. Scirica et al., “Prognostic performance of multiple biomarkers in patients with non-ST-segment elevation acute coronary syndrome: analysis from the MERLIN-TIMI 36 trial (Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST-Elevation Acute Coronary Syndromes-Thrombolysis in Myocardial Infarction 36),” Journal of the American College of Cardiology, vol. 63, no. 16, pp. 1644–1653, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. R. A. P. Weir, A. M. Miller, G. E. J. Murphy et al., “Serum soluble ST2: a potential novel mediator in left ventricular and infarct remodeling after acute myocardial infarction,” Journal of the American College of Cardiology, vol. 55, no. 3, pp. 243–250, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. G. Klug, H. J. Feistritzer, S. J. Reinstadler et al., “Association of aortic stiffness with biomarkers of myocardial wall stress after myocardial infarction,” International Journal of Cardiology, vol. 173, no. 2, pp. 253–258, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Reiter, R. Twerenbold, T. Reichlin et al., “Heart-type fatty acid-binding protein in the early diagnosis of acute myocardial infarction,” Heart, vol. 99, no. 10, pp. 708–714, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. S. J. Reinstadler, G. Klug, H. J. Feistritzer et al., “Relation of plasma adiponectin levels and aortic stiffness after acute ST-segment elevation myocardial infarction,” European Heart Journal: Acute Cardiovascular Care, vol. 3, no. 1, pp. 10–17, 2014. View at Publisher · View at Google Scholar
  25. F. Cappellini, S. Da Molin, S. Signorini et al., “Heart-type fatty acid-binding protein may exclude acute myocardial infarction on admission to emergency department for chest pain,” Acute Cardiac Care, vol. 15, no. 4, pp. 83–87, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. M. J. Brownstein, J. T. Russell, and H. Gainer, “Synthesis, transport and release of posterior pituitary hormones,” Science, vol. 207, no. 4429, pp. 373–378, 1980. View at Publisher · View at Google Scholar · View at Scopus
  27. C. P. Mahoney, E. Weinberger, C. Bryant, M. Ito, and J. L. Jameson, “Effects of aging on vasopressin production in a kindred with autosomal dominant neurohypophyseal diabetes insipidus due to the Deltae47 neurophysin mutation,” Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 2, pp. 870–876, 2002. View at Publisher · View at Google Scholar · View at Scopus
  28. C. Barat, L. Simpson, and E. Breslow, “Properties of human vasopressin precursor constructs: inefficient monomer folding in the absence of copeptin as a potential contributor to diabetes insipidus,” Biochemistry, vol. 43, no. 25, pp. 8191–8203, 2004. View at Publisher · View at Google Scholar · View at Scopus
  29. N. G. Morgenthaler, J. Struck, S. Jochberger, and M. W. Dünser, “Copeptin: clinical use of a new biomarker,” Trends in Endocrinology and Metabolism, vol. 19, no. 2, pp. 43–49, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. G. L. Robertson, E. A. Mahr, S. Athar, and T. Sinha, “Development and clinical application of a new method for the radioimmunoassay of arginine vasopressin in human plasma,” The Journal of Clinical Investigation, vol. 52, no. 9, pp. 2340–2352, 1973. View at Publisher · View at Google Scholar · View at Scopus
  31. N. G. Morgenthaler, J. Struck, C. Alonso, and A. Bergmann, “Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin,” Clinical Chemistry, vol. 52, no. 1, pp. 112–119, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. J. J. Preibisz, J. E. Sealey, J. H. Laragh, R. J. Cody, and B. B. Weksler, “Plasma and platelet vasopressin in essential hypertension and congestive heart failure,” Hypertension, vol. 5, no. 2, part 2, pp. I129–I138, 1983. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Katan and M. Christ-Crain, “The stress hormone copeptin: a new prognostic biomarker in acute illness,” Swiss Medical Weekly, vol. 140, article w13101, 2010. View at Google Scholar · View at Scopus
  34. B. Müller, N. Morgenthaler, D. Stolz et al., “Circulating levels of copeptin, a novel biomarker, in lower respiratory tract infections,” European Journal of Clinical Investigation, vol. 37, no. 2, pp. 145–152, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. N. G. Morgenthaler, B. Müller, J. Struck, A. Bergmann, H. Redl, and M. Christ-Crain, “Copeptin, a stable peptide of the arginine vasopressin precursor, is elevated in hemorrhagic and septic shock,” Shock, vol. 28, no. 2, pp. 219–226, 2007. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Katan, F. Fluri, N. G. Morgenthaler et al., “Copeptin: a novel, independent prognostic marker in patients with ischemic stroke,” Annals of Neurology, vol. 66, no. 6, pp. 799–808, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. G. Sang, J.-M. Du, Y.-Y. Chen, Y.-B. Chen, J.-X. Chen, and Y.-C. Chen, “Plasma copeptin levels are associated with prognosis of severe acute pancreatitis,” Peptides, vol. 51, pp. 4–8, 2014. View at Publisher · View at Google Scholar · View at Scopus
  38. S. Q. Khan, O. S. Dhillon, R. J. O'Brien et al., “C-terminal provasopressin (copeptin) as a novel and prognostic marker in acute myocardial infarction: leicester acute myocardial infarction peptide (LAMP) study,” Circulation, vol. 115, no. 16, pp. 2103–2110, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Katan, N. Morgenthaler, I. Widmer et al., “Copeptin, a stable peptide derived from the vasopressin precursor, correlates with the individual stress level,” Neuroendocrinology Letters, vol. 29, no. 3, pp. 341–346, 2008. View at Google Scholar · View at Scopus
  40. Y. L. Gu, A. A. Voors, F. Zijlstra et al., “Comparison of the temporal release pattern of copeptin with conventional biomarkers in acute myocardial infarction,” Clinical Research in Cardiology, vol. 100, no. 12, pp. 1069–1076, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. G. Szinnai, N. G. Morgenthaler, K. Berneis et al., “Changes in plasma copeptin, the C-terminal portion of arginine vasopressin during water deprivation and excess in healthy subjects,” The Journal of Clinical Endocrinology & Metabolism, vol. 92, no. 10, pp. 3973–3978, 2007. View at Publisher · View at Google Scholar · View at Scopus
  42. H. Hupf, D. Grimm, G. A. J. Riegger, and H. Schunkert, “Evidence for a vasopressin system in the rat heart,” Circulation Research, vol. 84, no. 3, pp. 365–370, 1999. View at Publisher · View at Google Scholar · View at Scopus
  43. C. Liebetrau, H. Nef, S. Szardien et al., “Release kinetics of copeptin in patients undergoing transcoronary ablation of septal hypertrophy,” Clinical Chemistry, vol. 59, no. 3, pp. 566–569, 2013. View at Publisher · View at Google Scholar · View at Scopus
  44. S. J. Reinstadler, G. Klug, H.-J. Feistritzer et al., “Long-term predictive value of copeptin after acute myocardial infarction: a cardiac magnetic resonance study,” International Journal of Cardiology, vol. 172, no. 2, pp. e359–e360, 2014. View at Publisher · View at Google Scholar · View at Scopus
  45. S. J. Reinstadler, G. Klug, H.-J. Feistritzer et al., “Association of copeptin with myocardial infarct size and myocardial function after ST segment elevation myocardial infarction,” Heart, vol. 99, no. 20, pp. 1525–1529, 2013. View at Publisher · View at Google Scholar · View at Scopus
  46. F. Stallone, R. Twerenbold, K. Wildi et al., “Prevalence, characteristics and outcome of non-cardiac chest pain and elevated copeptin levels,” Heart, vol. 100, no. 21, pp. 1708–1714, 2014. View at Publisher · View at Google Scholar
  47. T. Reichlin, W. Hochholzer, C. Stelzig et al., “Incremental value of copeptin for rapid rule out of acute myocardial infarction,” Journal of the American College of Cardiology, vol. 54, no. 1, pp. 60–68, 2009. View at Publisher · View at Google Scholar · View at Scopus
  48. T. Keller, S. Tzikas, T. Zeller et al., “Copeptin improves early diagnosis of acute myocardial infarction,” Journal of the American College of Cardiology, vol. 55, no. 19, pp. 2096–2106, 2010. View at Publisher · View at Google Scholar · View at Scopus
  49. M. J. Lipinski, R. O. Escárcega, F. D'Ascenzo et al., “A systematic review and collaborative meta-analysis to determine the incremental value of copeptin for rapid rule-out of acute myocardial infarction,” The American Journal of Cardiology, vol. 113, no. 9, pp. 1581–1591, 2014. View at Publisher · View at Google Scholar · View at Scopus
  50. T. Raskovalova, R. Twerenbold, P. O. Collinson et al., “Diagnostic accuracy of combined cardiac troponin and copeptin assessment for early rule-out of myocardial infarction: a systematic review and meta-analysis,” European Heart Journal: Acute Cardiovascular Care, vol. 3, no. 1, pp. 18–27, 2014. View at Publisher · View at Google Scholar
  51. S. von Haehling, J. Papassotiriou, N. G. Morgenthaler et al., “Copeptin as a prognostic factor for major adverse cardiovascular events in patients with coronary artery disease,” International Journal of Cardiology, vol. 162, no. 1, pp. 27–32, 2012. View at Publisher · View at Google Scholar · View at Scopus
  52. A. Gegenhuber, J. Struck, B. Dieplinger et al., “Comparative evaluation of B-type natriuretic peptide, mid-regional pro-A-type natriuretic peptide, mid-regional pro-adrenomedullin, and Copeptin to predict 1-year mortality in patients with acute destabilized heart failure,” Journal of Cardiac Failure, vol. 13, no. 1, pp. 42–49, 2007. View at Publisher · View at Google Scholar
  53. S. Neuhold, M. Huelsmann, G. Strunk et al., “Comparison of copeptin, B-type natriuretic peptide, and amino-terminal pro-B-type natriuretic peptide in patients with chronic heart failure: prediction of death at different stages of the disease,” Journal of the American College of Cardiology, vol. 52, no. 4, pp. 266–272, 2008. View at Publisher · View at Google Scholar · View at Scopus
  54. H. Bosselmann, M. Egstrup, K. Rossing et al., “Prognostic significance of cardiovascular biomarkers and renal dysfunction in outpatients with systolic heart failure: a long term follow-up study,” International Journal of Cardiology, vol. 170, no. 2, pp. 202–207, 2013. View at Publisher · View at Google Scholar · View at Scopus
  55. L. Balling, C. Kistorp, M. Schou et al., “Plasma copeptin levels and prediction of outcome in heart failure outpatients: relation to hyponatremia and loop diuretic doses,” Journal of Cardiac Failure, vol. 18, no. 5, pp. 351–358, 2012. View at Publisher · View at Google Scholar · View at Scopus
  56. A. Maisel, Y. Xue, K. Shah et al., “Increased 90-day mortality in patients with acute heart failure with elevated copeptin: secondary results from the Biomarkers in Acute Heart Failure (BACH) study,” Circulation: Heart Failure, vol. 4, no. 5, pp. 613–620, 2011. View at Publisher · View at Google Scholar · View at Scopus
  57. D. Bar-Shalom, M. K. Poulsen, L. M. Rasmussen et al., “Plasma copeptin as marker of cardiovascular disease in asymptomatic type 2 diabetes patients,” Diabetes and Vascular Disease Research, vol. 11, no. 6, pp. 448–450, 2014. View at Publisher · View at Google Scholar
  58. G. Velho, N. Bouby, S. Hadjadj et al., “Plasma copeptin and renal outcomes in patients with type 2 diabetes and albuminuria,” Diabetes Care, vol. 36, no. 11, pp. 3639–3645, 2013. View at Publisher · View at Google Scholar · View at Scopus
  59. I. J. Riphagen, W. E. Boertien, A. Alkhalaf et al., “Copeptin, a surrogate marker for arginine vasopressin, is associated with cardiovascular and all-cause mortality in patients with type 2 diabetes (ZODIAC-31),” Diabetes Care, vol. 36, no. 10, pp. 3201–3207, 2013. View at Publisher · View at Google Scholar · View at Scopus
  60. R. Seligman, J. Papassotiriou, N. G. Morgenthaler, M. Meisner, and P. J. Z. Teixeira, “Copeptin, a novel prognostic biomarker in ventilator-associated pneumonia,” Critical Care, vol. 12, no. 1, article R11, 2008. View at Publisher · View at Google Scholar · View at Scopus
  61. M. Kolditz, M. Halank, B. Schulte-Hubbert, S. Bergmann, S. Albrecht, and G. Höffken, “Copeptin predicts clinical deterioration and persistent instability in community-acquired pneumonia,” Respiratory Medicine, vol. 106, no. 9, pp. 1320–1328, 2012. View at Publisher · View at Google Scholar · View at Scopus
  62. D. Stolz, M. Christ-Crain, N. G. Morgenthaler et al., “Copeptin, C-reactive protein, and procalcitonin as prognostic biomarkers in acute exacerbation of COPD,” Chest, vol. 131, no. 4, pp. 1058–1067, 2007. View at Publisher · View at Google Scholar · View at Scopus
  63. Q. Zhang, G. Dong, X. Zhao, M. Wang, and C. S. Li, “Prognostic significance of hypothalamic-pituitary-adrenal axis hormones in early sepsis: a study performed in the emergency department,” Intensive Care Medicine, vol. 40, no. 10, pp. 1499–1508, 2014. View at Publisher · View at Google Scholar
  64. P. Ostadal, A. Kruger, V. Zdrahalova et al., “Blood levels of copeptin on admission predict outcomes in out-of-hospital cardiac arrest survivors treated with therapeutic hypothermia,” Critical Care, vol. 16, no. 5, article R187, 2012. View at Publisher · View at Google Scholar · View at Scopus
  65. N. P. Nickel, R. Lichtinghagen, H. Golpon et al., “Circulating levels of copeptin predict outcome in patients with pulmonary arterial hypertension,” Respiratory Research, vol. 14, no. 1, article 130, 2013. View at Publisher · View at Google Scholar · View at Scopus
  66. G. M. De Marchis, A. Weck, H. Audebert et al., “Copeptin for the prediction of recurrent cerebrovascular events after transient ischemic attack: results from the CoRisk study,” Stroke, vol. 45, no. 10, pp. 2918–2923, 2014. View at Publisher · View at Google Scholar
  67. W.-J. Tu, X. Dong, S.-J. Zhao, D.-G. Yang, and H. Chen, “Prognostic value of plasma neuroendocrine biomarkers in patients with acute ischaemic stroke,” Journal of Neuroendocrinology, vol. 25, no. 9, pp. 771–778, 2013. View at Publisher · View at Google Scholar · View at Scopus
  68. J.-L. Zhang, C.-H. Yin, Y. Zhang, L.-B. Zhao, H.-J. Fu, and J.-C. Feng, “Plasma copeptin and long-term outcomes in acute ischemic stroke,” Acta Neurologica Scandinavica, vol. 128, no. 6, pp. 372–380, 2013. View at Publisher · View at Google Scholar · View at Scopus
  69. D. B. Yang, W. H. Yu, X. Q. Dong et al., “Plasma copeptin level predicts acute traumatic coagulopathy and progressive hemorrhagic injury after traumatic brain injury,” Peptides, vol. 58, pp. 26–29, 2014. View at Publisher · View at Google Scholar
  70. G.-F. Yu, Q. Huang, W.-M. Dai et al., “Prognostic value of copeptin: one-year outcome in patients with traumatic brain injury,” Peptides, vol. 33, no. 1, pp. 164–169, 2012. View at Publisher · View at Google Scholar · View at Scopus
  71. X. Q. Dong, M. Huang, S. B. Yang, W. H. Yu, and Z. Y. Zhang, “Copeptin is associated with mortality in patients with traumatic brain injury,” Journal of Trauma—Injury, Infection and Critical Care, vol. 71, no. 5, pp. 1194–1198, 2011. View at Publisher · View at Google Scholar · View at Scopus
  72. W.-H. Yu, W.-H. Wang, X.-Q. Dong et al., “Prognostic significance of plasma copeptin detection compared with multiple biomarkers in intracerebral hemorrhage,” Clinica Chimica Acta, vol. 433, pp. 174–178, 2014. View at Publisher · View at Google Scholar · View at Scopus
  73. Z. J. Wei, Y. Q. Ou, X. Li, and H. Li, “The 90-day prognostic value of copeptin in acute intracerebral hemorrhage,” Neurological Sciences, vol. 35, no. 11, pp. 1673–1679, 2014. View at Publisher · View at Google Scholar
  74. V. Maravic-Stojkovic, L. J. Lausevic-Vuk, M. Obradovic et al., “Copeptin level after carotid endarterectomy and perioperative stroke,” Angiology, vol. 65, no. 2, pp. 122–129, 2014. View at Publisher · View at Google Scholar · View at Scopus
  75. S. Dong, C. L. Li, W. D. Liang, M. H. Chen, Y. T. Bi, and X. W. Li, “Postoperative plasma copeptin levels independently predict delirium and cognitive dysfunction after coronary artery bypass graft surgery,” Peptides, vol. 59, pp. 70–74, 2014. View at Google Scholar
  76. X. Li, X.-C. Yang, Q.-M. Sun, X.-D. Chen, and Y.-C. Li, “Brain natriuretic peptide and copeptin levels are associated with cardiovascular disease in patients with chronic kidney disease,” Chinese Medical Journal, vol. 126, no. 5, pp. 823–827, 2013. View at Publisher · View at Google Scholar · View at Scopus
  77. W. E. Boertien, E. Meijer, D. Zittema et al., “Copeptin, a surrogate marker for vasopressin, is associated with kidney function decline in subjects with autosomal dominant polycystic kidney disease,” Nephrology Dialysis Transplantation, vol. 27, no. 11, pp. 4131–4137, 2012. View at Publisher · View at Google Scholar · View at Scopus
  78. D. Zittema, W. E. Boertien, A. P. van Beek et al., “Vasopressin, copeptin, and renal concentrating capacity in patients with autosomal dominant polycystic kidney disease without renal impairment,” Clinical Journal of the American Society of Nephrology, vol. 7, no. 6, pp. 906–913, 2012. View at Publisher · View at Google Scholar · View at Scopus
  79. L. Pang, H. L. Wang, Z. H. Wang et al., “Plasma copeptin as a predictor of intoxication severity and delayed neurological sequelae in acute carbon monoxide poisoning,” Peptides, vol. 59, pp. 89–93, 2014. View at Google Scholar
  80. B. Karbek, M. Ozbek, M. Karakose et al., “Copeptin, a surrogate marker for arginine vasopressin, is associated with cardiovascular risk in patients with polycystic ovary syndrome,” Journal of Ovarian Research, vol. 7, no. 1, article 31, 2014. View at Publisher · View at Google Scholar · View at Scopus
  81. A. Tuten, M. Kucur, M. Imamoglu et al., “Copeptin is associated with the severity of endometriosis,” Archives of Gynecology and Obstetrics, vol. 290, no. 1, pp. 75–82, 2014. View at Publisher · View at Google Scholar · View at Scopus
  82. E. H. Yeung, A. Liu, J. L. Mills et al., “Increased levels of copeptin before clinical diagnosis of preelcampsia,” Hypertension, vol. 64, no. 6, pp. 1362–1367, 2014. View at Publisher · View at Google Scholar
  83. E. Zulfikaroglu, M. Islimye, E. A. Tonguc et al., “Circulating levels of copeptin, a novel biomarker in pre-eclampsia,” The Journal of Obstetrics and Gynaecology Research, vol. 37, no. 9, pp. 1198–1202, 2011. View at Publisher · View at Google Scholar · View at Scopus
  84. F. K. Isman, B. Zulfikaroglu, B. Isbilen et al., “Copeptin is a predictive biomarker of severity in acute pancreatitis,” American Journal of Emergency Medicine, vol. 31, no. 4, pp. 690–692, 2013. View at Publisher · View at Google Scholar · View at Scopus
  85. J.-P. Moreno, E. Grandclement, E. Monnet et al., “Plasma copeptin, a possible prognostic marker in cirrhosis,” Liver International, vol. 33, no. 6, pp. 843–851, 2013. View at Publisher · View at Google Scholar · View at Scopus
  86. K. S. Akinlade, A. D. Atere, S. K. Rahamon, and J. A. Olaniyi, “Serum levels of copeptin, C-reactive protein and cortisol in different severity groups of sickle cell anaemia,” Nigerian Journal of Physiological Sciences, vol. 28, no. 2, pp. 159–164, 2013. View at Google Scholar
  87. C. Meune, S. Zuily, K. Wahbi, Y.-E. Claessens, S. Weber, and C. Chenevier-Gobeaux, “Combination of copeptin and high-sensitivity cardiac troponin T assay in unstable angina and non-ST-segment elevation myocardial infarction: a pilot study,” Archives of Cardiovascular Diseases, vol. 104, no. 1, pp. 4–10, 2011. View at Publisher · View at Google Scholar · View at Scopus
  88. E. Giannitsis, T. Kehayova, M. Vafaie, and H. A. Katus, “Combined testing of high-sensitivity troponin T and copeptin on presentation at prespecified cutoffs improves rapid rule-out of non-ST-segment elevation myocardial infarction,” Clinical Chemistry, vol. 57, no. 10, pp. 1452–1455, 2011. View at Publisher · View at Google Scholar · View at Scopus
  89. P. Ray, S. Charpentier, C. Chenevier-Gobeaux et al., “Combined copeptin and troponin to rule out myocardial infarction in patients with chest pain and a history of coronary artery disease,” The American Journal of Emergency Medicine, vol. 30, no. 3, pp. 440–448, 2012. View at Publisher · View at Google Scholar · View at Scopus
  90. A. Maisel, C. Mueller, S.-X. Neath et al., “Copeptin helps in the early detection of patients with acute myocardial infarction: primary results of the CHOPIN trial (Copeptin Helps in the early detection of Patients with acute myocardial INfarction),” Journal of the American College of Cardiology, vol. 62, no. 2, pp. 150–160, 2013. View at Publisher · View at Google Scholar · View at Scopus
  91. M. Sebbane, S. Lefebvre, N. Kuster et al., “Early rule out of acute myocardial infarction in ED patients: Value of combined high-sensitivity cardiac troponin T and ultrasensitive copeptin assays at admission,” The American Journal of Emergency Medicine, vol. 31, no. 9, pp. 1302–1308, 2013. View at Publisher · View at Google Scholar · View at Scopus
  92. C. Chenevier-Gobeaux, Y. Freund, Y.-E. Claessens et al., “Copeptin for rapid rule out of acute myocardial infarction in emergency department,” International Journal of Cardiology, vol. 166, no. 1, pp. 198–204, 2013. View at Publisher · View at Google Scholar · View at Scopus
  93. J. Thelin, C. Borna, D. Erlinge, and B. Öhlin, “The combination of high sensitivity troponin T and copeptin facilitates early rule-out of ACS: a prospective observational study,” BMC Cardiovascular Disorders, vol. 13, article 42, 2013. View at Publisher · View at Google Scholar · View at Scopus
  94. C. Balmelli, C. Meune, R. Twerenbold et al., “Comparison of the performances of cardiac troponins, including sensitive assays, and copeptin in the diagnostic of acute myocardial infarction and long-term prognosis between women and men,” American Heart Journal, vol. 166, no. 1, pp. 30–37, 2013. View at Publisher · View at Google Scholar · View at Scopus
  95. P. Collinson, D. Gaze, and S. Goodacre, “Comparison of contemporary troponin assays with the novel biomarkers, heart fatty acid binding protein and copeptin, for the early confirmation or exclusion of myocardial infarction in patients presenting to the emergency department with chest pain,” Heart, vol. 100, no. 2, pp. 140–145, 2014. View at Publisher · View at Google Scholar · View at Scopus
  96. J. Duchenne, S. Mestres, and N. Dublanchet, “Diagnostic accuracy of copeptin sensitivity and specificity in patients with suspected non-ST-elevation myocardial infarction with troponin I below the 99th centile at presentation,” BMJ Open, vol. 4, no. 3, Article ID e004449corr1, 2014. View at Publisher · View at Google Scholar · View at Scopus
  97. P. Llorens, M. Sánchez, P. Herrero, F. J. Martín-Sánchez, P. Piñera, and Ò. Miró, “The utility of copeptin in the emergency department for non-ST-elevation myocardial infarction rapid rule out: COPED-MIRRO study,” European Journal of Emergency Medicine, vol. 21, no. 3, pp. 220–229, 2014. View at Publisher · View at Google Scholar · View at Scopus
  98. M. Karakas, J. L. Januzzi Jr., J. Meyer et al., “Copeptin does not add diagnostic information to high-sensitivity troponin t in low- to intermediate-risk patients with acute chest pain: results from the rule out myocardial infarction by computed tomography (ROMICAT) Study,” Clinical Chemistry, vol. 57, no. 8, pp. 1137–1145, 2011. View at Publisher · View at Google Scholar · View at Scopus
  99. S. Charpentier, B. Lepage, F. Maupas-Schwalm et al., “Copeptin improves the diagnostic performance of sensitive troponin I-ultra but cannot rapidly rule out non-ST-elevation myocardial infarction at presentation to an emergency department,” Annals of Emergency Medicine, vol. 61, no. 5, pp. 549.e1–558.e1, 2013. View at Publisher · View at Google Scholar · View at Scopus
  100. M. Weber, O. Bazzino, J. L. N. Estrada et al., “Improved diagnostic and prognostic performance of a new high-sensitive troponin T assay in patients with acute coronary syndrome,” The American Heart Journal, vol. 162, no. 1, pp. 81–88, 2011. View at Publisher · View at Google Scholar · View at Scopus
  101. T. Keller, T. Zeller, F. Ojeda et al., “Serial changes in highly sensitive troponin I assay and early diagnosis of myocardial infarction,” Journal of the American Medical Association, vol. 306, no. 24, pp. 2684–2693, 2011. View at Publisher · View at Google Scholar · View at Scopus
  102. R. Body, S. Carley, G. McDowell et al., “Rapid exclusion of acute myocardial infarction in patients with undetectable troponin using a high-sensitivity assay,” Journal of the American College of Cardiology, vol. 58, no. 13, pp. 1332–1339, 2011. View at Publisher · View at Google Scholar · View at Scopus
  103. N. Bandstein, R. Ljung, M. Johansson, and M. J. Holzmann, “Undetectable high-sensitivity cardiac troponin T level in the emergency department and risk of myocardial infarction,” Journal of the American College of Cardiology, vol. 63, no. 23, pp. 2569–2578, 2014. View at Publisher · View at Google Scholar
  104. M. Mockel, J. Searle, C. Hamm et al., “Early discharge using single cardiac troponin and copeptin testing in patients with suspected acute coronary syndrome (ACS): a randomized, controlled clinical process study,” European Heart Journal, 2014. View at Publisher · View at Google Scholar
  105. P. Collinson, S. Goodacre, D. Gaze, and A. Gray, “Very early diagnosis of chest pain by point-of-care testing: comparison of the diagnostic efficiency of a panel of cardiac biomarkers compared with troponin measurement alone in the RATPAC trial,” Heart, vol. 98, no. 4, pp. 312–318, 2012. View at Publisher · View at Google Scholar · View at Scopus
  106. M. Than, L. Cullen, C. M. Reid et al., “A 2-h diagnostic protocol to assess patients with chest pain symptoms in the Asia-Pacific region (ASPECT): a prospective observational validation study,” The Lancet, vol. 377, no. 9771, pp. 1077–1084, 2011. View at Publisher · View at Google Scholar · View at Scopus
  107. D. Kelly, I. B. Squire, S. Q. Khan et al., “C-terminal provasopressin (copeptin) is associated with left ventricular dysfunction, remodeling, and clinical heart failure in survivors of myocardial infarction,” Journal of Cardiac Failure, vol. 14, no. 9, pp. 739–745, 2008. View at Publisher · View at Google Scholar · View at Scopus
  108. M. Möckel and J. Searle, “The positive predictive value of ct-proAVP (copeptin) in patients with STEMI,” Heart, vol. 99, no. 20, p. 1475, 2013. View at Publisher · View at Google Scholar · View at Scopus
  109. H. Narayan, O. S. Dhillon, P. A. Quinn et al., “C-terminal provasopressin (copeptin) as a prognostic marker after acute non-ST elevation myocardial infarction: leicester acute myocardial infarction peptide II (LAMP II) study,” Clinical Science, vol. 121, no. 2, pp. 79–89, 2011. View at Publisher · View at Google Scholar · View at Scopus
  110. D. Afzali, M. Erren, H. J. Pavenstädt et al., “Impact of copeptin on diagnosis, risk stratification, and intermediate-term prognosis of acute coronary syndromes,” Clinical Research in Cardiology, vol. 102, no. 10, pp. 755–763, 2013. View at Publisher · View at Google Scholar · View at Scopus
  111. M. Sanchez, P. Llorens, P. Herrero, F. J. Martin-Sanchez, P. Pinera, and O. Miro, “The utility of copeptin in the emergency department as a predictor of adverse outcomes in non-ST-elevation acute coronary syndrome: the COPED-PAO study,” Emergency Medicine Journal, vol. 31, no. 4, pp. 286–291, 2014. View at Google Scholar
  112. M. Potocki, T. Reichlin, S. Thalmann et al., “Diagnostic and prognostic impact of copeptin and high-sensitivity cardiac troponin T in patients with pre-existing coronary artery disease and suspected acute myocardial infarction,” Heart, vol. 98, no. 7, pp. 558–565, 2012. View at Publisher · View at Google Scholar · View at Scopus