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Disease Markers
Volume 2015, Article ID 616541, 6 pages
http://dx.doi.org/10.1155/2015/616541
Research Article

Expression of Spindle and Kinetochore-Associated Protein 1 Is Associated with Poor Prognosis in Papillary Thyroid Carcinoma

Department of Head and Neck Surgery, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi, Xinjiang 830011, China

Received 6 February 2015; Accepted 16 April 2015

Academic Editor: Kishore Chaudhry

Copyright © 2015 Chao Dong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. Spindle and kinetochore-associated protein 1 (SKA1) is one subtype of SKA, whose protein can make spindle microtubules attach steadily to the kinetochore in the middle of mitosis. At present, there are fewer researches on the relationship between SKA1 expression and tumor development. Methods. In this study, immunohistochemical analysis was used to determine the expression of SKA1 in papillary thyroid carcinoma (PTC) and adjacent tissues. We used quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot analysis to further verify the results. Results. We found that SKA1 expression was significantly higher in PTC tissues than normal adjacent tissues . There existed a significant correlation among a higher SKA1 expression, including lymphoid node , clinical stage , and extrathyroid invasion . Survival analysis showed high SKA1 expression in PTC patients more likely to relapse after surgery. Conclusion. High SKA1 expression is predictive of poor prognosis of PTC, implying that SKA1 may be a promising new target for targeted therapies for PTC.