Serum MicroRNA Profiles Serve as Novel Biomarkers for the Diagnosis of Alzheimer’s Disease

Table 1

Demographic and clinical features of the participants whose sera were examined with individual RT-qPCR assays in the training set and the validation set^a.

Variables	NDC (n = 123)	AD (n = 127)	MCI (n = 30)	VD (n = 30)	-value (NDC, AD & NDC, MCI)
Age	79.5 ± 6.8	79.3 ± 8.9	81.1 ± 6.8	82.1 ± 6.8	0.8951^b; 0.2348^b
Age group					0.2598^c; 0.3876^c
<65 years	4 (3.3%)	8 (6.3%)	2 (6.7%)	1 (3.3%)
≥65 years	119 (96.7%)	119 (93.7%)	28 (93.3%)	29 (96.7%)
Gender					0.5412^c; 0.0895^c
Male	65 (52.8%)	72 (56.7%)	21 (70.0%)	26 (86.7%)
Female	58 (47.2%)	55 (43.3%)	9 (30.0%)	4 (13.3%)
Years of education	9.5 ± 5.4	8.4 ± 5.2	11.4 ± 4.1	10.5 ± 5.3	0.2017^b; 0.1687^b
MMSE	27.2 ± 1.3	11.5 ± 7.7	25.6 ± 2.3	8.7 ± 9.0	<0.0001^b; <0.0001^b

^aData are presented as the means ± SD, ^bStudent’s -test, and ^ctwo-sided test.