Serum MicroRNA Profiles Serve as Novel Biomarkers for the Diagnosis of Alzheimer’s Disease

Table 2

Differentially expressed miRNAs in AD serum samples compared with control samples in training and validation sets^a.

miRNA	Training set				Validation set
	NC (n = 48)	AD (n = 48)	Fold change	-value^b	NC (n = 75)	AD (n = 79)	Fold change	-value^b
miR-31	10.54 ± 1.19	5.17 ± 0.37	0.491	0.0002	12.39 ± 1.45	5.77 ± 0.84	0.466	<0.0001
miR-93	24.18 ± 2.23	11.72 ± 1.22	0.485	<0.0001	20.63 ± 2.28	10.12 ± 0.98	0.491	<0.0001
miR-143	14.27 ± 1.15	7.03 ± 0.63	0.493	<0.0001	11.98 ± 1.58	5.22 ± 0.78	0.436	<0.0001
miR-146a	73.93 ± 7.16	36.40 ± 2.76	0.492	<0.0001	57.91 ± 6.68	27.26 ± 3.25	0.471	<0.0001

^aThe absolute concentrations of miRNAs are presented as the means ± SEM (fmol/L).
^bMann-Whitney unpaired rank-sum test.