Influence of GSTM1, GSTT1, and GSTP1 Polymorphisms on Type 2 Diabetes Mellitus and Diabetic Sensorimotor Peripheral Neuropathy Risk
Table 4
Baseline characteristics of studied patients with T2DM.
Variable
DSPN No
DSPN Yes
p value
Patients number
42
42
Male/female, No. (%)
23 (54.8)/19 (45.2)
27 (64.3)/15 (35.7)
0.34
Age (years)
60.1 ± 7.5
66.2 ± 9.3
0.0001
Height m2
1.65 ± 0.06
1.68 ± 0.07
0.04
Weight kg
85.4 ± 13.8
83.0 ± 12.7
0.40
Age at diabetes diagnosis (years)
53.7 ± 8.5
55.5 ± 10.8
0.38
Diabetes duration (years)
5.5 (1–17)
10 (1–29)
0.0006
GSTP1, No. (%)
Ile/Ile
26 (61.9)
23 (54.8)
0.68
Ile/Val
12 (28.6)
12 (28.6)
Val/Val
4 (9.5)
7 (16.7)
GSTT1, No. (%)
Null
8 (19.0)
7 (16.7)
0.76
Present
34 (81.0)
35 (83.3)
GSTM1, No. (%)
Null
22 (52.4)
18 (42.9)
0.38
Present
20 (47.6)
24 (57.1)
Body mass index (kg/m2)
29.2 ± 4.3
31.1 ± 5.1
0.05
Systolic BP (mmHg)
152.5 ± 22.2
154.2 ± 28.4
0.75
Diastolic BP (mmHg)
89.1 ± 9.8
90.5 ± 17.1
0.62
Hypertension (yes), No. (%)
40 (95.2)
41 (97.6)
0.55
Creatinine (mg/dL)
0.87 ± 0.18
0.94 ± 0.28
0.04
Blood urea nitrogen (mg/dL)
36.8 ± 12.6
42.3 ± 15.7
0.08
HDL cholesterol (mg/dL)
43.5 ± 11.8
41.8 ± 12.2
0.52
LDL cholesterol (mg/dL)
110.3 ± 33.5
108.5 ± 52.2
0.84
Total cholesterol (mg/dL)
184.7 ± 40.7
184.3 ± 63.3
0.97
Triglycerides (mg %)
142.4 (70–286.1)
153.1 (59.1–798.0)
0.92
Microalbuminuria (mg/L)
3.9 (3–234.1)
13.5 (3–1293)
0.006
HbA1c
6.95 ± 1.01
7.3 ± 1.2
0.24
Statins (yes), No. (%)
24 (57.1)
30 (71.4)
0.17
Fibrates (yes), No. (%)
1 (2.4)
1 (2.4)
0.98
Insulin (yes), No. (%)
13 (31.0)
23 (54.8)
0.02
Data are shown as mean ± SD, as median (min-max), or as OR: odd ratio, CI: confidence interval, and No.: number. Mann Whitney test, DSPN No: without DSPN, and DSPN Yes: with DSPN.
