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Disease Markers
Volume 2015 (2015), Article ID 658141, 11 pages
http://dx.doi.org/10.1155/2015/658141
Research Article

Upregulated Expression of SOX4 Is Associated with Tumor Growth and Metastasis in Nasopharyngeal Carcinoma

1Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226000, China
2Department of Pathology, Medical School of Nantong University, Nantong, Jiangsu, China

Received 16 May 2015; Accepted 15 September 2015

Academic Editor: Chih-Hung Ku

Copyright © 2015 Si Shi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Al-Sarraf and M. S. Reddy, “Nasopharyngeal carcinoma,” Current Treatment Options in Oncology, vol. 3, no. 1, pp. 21–32, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Hildesheim and C.-P. Wang, “Genetic predisposition factors and nasopharyngeal carcinoma risk: a review of epidemiological association studies, 2000-2011. Rosetta Stone for NPC: genetics, viral infection, and other environmental factors,” Seminars in Cancer Biology, vol. 22, no. 2, pp. 107–116, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. B. B. Y. Ma and A. T. C. Chan, “Recent perspectives in the role of chemotherapy in the management of advanced nasopharyngeal carcinoma,” Cancer, vol. 103, no. 1, pp. 22–31, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. Q. Wen, J. Li, W. Wang et al., “Increased expression of flotillin-2 protein as a novel biomarker for lymph node metastasis in nasopharyngeal carcinoma,” PLoS ONE, vol. 9, no. 7, Article ID e101676, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. K. W. Lo, K. F. To, and D. P. Huang, “Focus on nasopharyngeal carcinoma,” Cancer Cell, vol. 5, no. 5, pp. 423–428, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. M. van de Wetering, M. Oosterwegel, K. Van Norren, and H. Clevers, “Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes,” The EMBO Journal, vol. 12, no. 10, pp. 3847–3854, 1993. View at Google Scholar · View at Scopus
  7. P. Dy, A. Penzo-Méndez, H. Wang, C. E. Pedraza, W. B. Macklin, and V. Lefebvre, “The three SoxC proteins—Sox4, Sox11 and Sox12—exhibit overlapping expression patterns and molecular properties,” Nucleic Acids Research, vol. 36, no. 9, pp. 3101–3117, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. S. J. Vervoort, R. van Boxtel, and P. J. Coffer, “The role of SRY-related HMG box transcription factor 4 (SOX4) in tumorigenesis and metastasis: Friend or foe?” Oncogene, vol. 32, no. 29, pp. 3397–3409, 20132. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Bergsland, D. Ramsköld, C. Zaouter, S. Klum, R. Sandberg, and J. Muhr, “Sequentially acting Sox transcription factors in neural lineage development,” Genes and Development, vol. 25, no. 23, pp. 2453–2464, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Zhang, Q. Liang, Y. Lei et al., “SOX4 induces epithelial-mesenchymal transition and contributes to breast cancer progression,” Cancer Research, vol. 72, no. 17, pp. 4597–4608, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. S. D. Castillo, A. Matheu, N. Mariani et al., “Novel transcriptional targets of the SRY-HMG box transcription factor SOX4 link its expression to the development of small cell lung cancer,” Cancer Research, vol. 72, no. 1, pp. 176–186, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. H. Ikushima, T. Todo, Y. Ino, M. Takahashi, K. Miyazawa, and K. Miyazono, “Autocrine TGF-β signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors,” Cell Stem Cell, vol. 5, no. 5, pp. 504–514, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. P. Liu, S. Ramachandran, M. A. Seyed et al., “Sex-determining region Y box 4 is a transforming oncogene in human prostate cancer cells,” Cancer Research, vol. 66, no. 8, pp. 4011–4019, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. C.-L. Fang, Y.-C. Hseu, Y.-F. Lin et al., “Clinical and prognostic association of transcription factor SOX4 in gastric cancer,” PLoS ONE, vol. 7, no. 12, Article ID e52804, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Aaboe, K. Birkenkamp-Demtroder, C. Wiuf et al., “SOX4 expression in bladder carcinoma: clinical aspects and in vitro functional characterization,” Cancer Research, vol. 66, no. 7, pp. 3434–3442, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. S. M. Jafarnejad, A. A. Wani, M. Martinka, and G. Li, “Prognostic significance of Sox4 expression in human cutaneous melanoma and its role in cell migration and invasion,” The American Journal of Pathology, vol. 177, no. 6, pp. 2741–2752, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. C. Wang, H. Zhao, J. Lu et al., “Clinicopathological significance of SOX4 expression in primary gallbladder carcinoma,” Diagnostic Pathology, vol. 7, no. 1, article 41, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. Z. Liu, X. Li, X. He et al., “Decreased expression of updated NESG1 in nasopharyngeal carcinoma: its potential role and preliminarily functional mechanism,” International Journal of Cancer, vol. 128, no. 11, pp. 2562–2571, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Chen, X. Li, S. Wu et al., “Expression of HIF-1α and CAIX in nasopharyngeal carcinoma and their correlation with patients' prognosis,” Medical Oncology, vol. 31, no. 12, article 304, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. A. T. C. Chan, S. F. Leung, R. K. C. Ngan et al., “Overall survival after concurrent cisplatin-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma,” Journal of the National Cancer Institute, vol. 97, no. 7, pp. 536–539, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. C.-M. Lin, C.-L. Fang, Y.-C. Hseu et al., “Clinical and prognostic implications of transcription factor SOX4 in patients with colon cancer,” PLoS ONE, vol. 8, no. 6, Article ID e67128, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. C. C. Pan, J. Lu, J.-R. Yu et al., “Challenges in the modification of the M1 stage of the TNM staging system for nasopharyngeal carcinoma: a study of 1027 cases and review of the literature,” Experimental and Therapeutic Medicine, vol. 4, no. 2, pp. 334–338, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. Y.-L. Liao, Y.-M. Sun, G.-Y. Chau et al., “Identification of SOX4 target genes using phylogenetic footprinting-based prediction from expression microarrays suggests that overexpression of SOX4 potentiates metastasis in hepatocellular carcinoma,” Oncogene, vol. 27, no. 42, pp. 5578–5589, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. J. P. Thiery, H. Acloque, R. Y. J. Huang, and M. A. Nieto, “Epithelial-mesenchymal transitions in development and disease,” Cell, vol. 139, no. 5, pp. 871–890, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. L. Wang, J. Zhang, X. Yang et al., “SOX4 is associated with poor prognosis in prostate cancer and promotes epithelial-mesenchymal transition in vitro,” Prostate Cancer and Prostatic Diseases, vol. 16, no. 4, pp. 301–307, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. B. Baujat, H. Audry, J. Bourhis et al., “Chemotherapy in locally advanced nasopharyngeal carcinoma: an individual patient data meta-analysis of eight randomized trials and 1753 patients,” International Journal of Radiation Oncology Biology Physics, vol. 64, no. 1, pp. 47–56, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. R.-Y. Liu, Z. Dong, J. Liu et al., “Role of eIF3a in regulating cisplatin sensitivity and in translational control of nucleotide excision repair of nasopharyngeal carcinoma,” Oncogene, vol. 30, no. 48, pp. 4814–4823, 2011. View at Publisher · View at Google Scholar · View at Scopus