Disease Markers / 2015 / Article / Tab 3

Research Article

Assessment of Immunological Biomarkers in the First Year after Heart Transplantation

Table 3

Mean, standard deviations, and values of the different immunological parameters CD25, CD95, IL2, IFN, plasmacytoid and myeloid dendritic cells, IP10, and MIG in recipients with and without acute cellular rejection at three different time points during the first year after heart transplantation. values refer to the comparison of the two groups: recipients with acute cellular rejections and recipients without acute cellular rejections.

1st quarter2nd quarter2nd half year
Mean ± SD valueMean ± SD valueMean ± SD value

CD25
 Without ACR34.9%  ±  20.7%0.28733.5%  ±  21.0%0.39231.4%  ±  20.1%0.592
 With ACR22.7%  ±  26.9%44.1%  ±  27.6%37.2%  ±  27.1%
CD95
 Without ACR42.2%  ±  23.2%0.03343.6%  ±  27.3%0.28842.8%  ±  28.5%0.510
 With ACR15.1%  ±  19.2%59.6%  ±  23.8%52.5%  ±  29.4%
IL-2
 Without ACR9.9%  ±  12.2%0.53715.2%  ±  13.1%0.15018.0%  ±  15.0%0.130
 With ACR5.9%  ±  9.1%27.5%  ±  16.6%30.9%  ±  16.9%
IFN
 Without ACR10.1%  ±  11.1%0.46116.9%  ±  12.2%0.20124.9%  ±  21.5%0.501
 With ACR19.3%  ±  21.9%27.2%  ±  17.6%33.2%  ±  26.3%
pDCs
 Without ACR18.8%  ±  12.4%0.79726.2%  ±  11.4%0.40431.5%  ±  12.3%0.443
 With ACR17.1%  ±  14.9%32.0%  ±  7.3%36.6%  ±  7.9%
mDCs
 Without ACR39.6%  ±  20.2%0.46549.1%  ±  15.9%0.84748.7%  ±  21.8%0.519
 With ACR48.2%  ±  30.9%51.0%  ±  11.2%40.5%  ±  17.4%
pDC/mDC ratio
 Without ACR0.8  ±  1.30.7020.7  ±  0.80.9221.1  ±  1.30.915
 With ACR0.5  ±  0.40.7  ±  0.31.2  ±  0.8
IP10
 Without ACR36.5 pg/mL  ±  33.4 pg/mL0.28929.9 pg/mL  ±  21.6 pg/mL0.01739.8 pg/mL  ±  38.7 pg/mL0.511
 With ACR57.7 pg/mL  ±  59.9 pg/mL67.5 pg/mL  ±  33.7 pg/mL54.0 pg/mL  ±  58.3 pg/mL
MIG
 Without ACR33.5 pg/mL  ±  41.6 pg/mL0.41822.7 pg/mL  ±  17.6 pg/mL0.78325.5 pg/mL  ±  14.4 pg/mL0.891
 With ACR16.1 pg/mL  ±  7.8 pg/mL26.3 pg/mL  ±  11.8 pg/mL24.5 pg/mL  ±  12.0 pg/mL

ACR, acute cellular rejection; CD25, alpha chain of the interleukin-2 receptor; CD95, Fas receptor; IFN, interferon g; IL-2, interleukin-2; IP10, CXC chemokine ligand 10; mDCs, myeloid dendritic cells; MIG, CXC chemokine ligand 9; pDCs, plasmacytoid dendritic cells; SD, standard deviation.