First-Trimester Uterine Artery Doppler Analysis in the Prediction of Later Pregnancy Complications

Table 3

External validation of multiparametric models for the prediction of late preeclampsia (>34 weeks).

Study	Population	Incidence of late preeclampsia	Predictive models tested	Detection rate (%) at 10% false positive rate
				Reported	Observed
			Poon [38]; (lowest UtA-PI)	45.3	38.5
			Poon [38]; (mean UtA-PI)	46.9	41
Farina et al. [39]	554 Mediterranean women	7%	Poon [38]; (highest UtA-PI)	46.1	43.6
			Poon [54]	41.1	35.9
			Poon [58]	57	84.6
Oliveira et al. [61]	2962 American women	4.1–5%	Parra-Cordero [52]; Scazzocchio [55]	29; 40	18; 31
Park et al. [62]	3066 Australian women	2.3%	Poon [58]	57	35.2
Skråstad et al. [63]	541 nulliparous Norwegian women	3.7%	Akolekar [60]; PREDICTOR posterior^*	N/A; N/A	30; 30

UtA-PI = uterine artery pulsatility index.
^*Proprietary predictive model (PerkinElmer, Waltham, MA, USA) incorporating BMI, ethnicity, parity, family history of preeclampsia, chronic hypertension, MAP, UtA lowest PI, PlGF, and PAPP-A.