Serum Metabolites as Potential Biomarkers for Diagnosis of Knee Osteoarthritis

Table 1

Demographic description of patients and healthy controls in the study.

	Control			value
		Mild	Severe	OA versus HC	m-OA versus s-OA
Number	20	20	20	NA	NA
Gender (male/female)	10/10	10/10	10/10	1.0	1.0
Age (mean ± SD)	56.3 ± 7.9	59.2 ± 8.3	57.0 ± 5.2	0.22	0.64
BMI	24.2 ± 2.3	27.5 ± 2.0	28.2 ± 3.4	0.16	0.52
CRP (mg/L)	0.7 ± 0.2	1.9 ± 0.6	2.6 ± 0.8	0.02	0.04
WBC (×10^9/L)	4.7 ± 2.4	5.1 ± 3.1	5.4 ± 3.9	0.74	0.88
Creatinine (mol/L)	55.7 ± 21.2	58.9 ± 24.1	62.7 ± 29.6	0.84	0.79

OA, osteoarthritis; m-OA, mild osteoarthritis; s-OA, severe osteoarthritis; BMI, body mass index. CRP, C reaction protein; WBC, white blood cell.
Patients with keen OA of K-L grades II and III were set as mild group and with K-L grade IV were set as severe group.