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Disease Markers
Volume 2015 (2015), Article ID 690878, 16 pages
Research Article

OGG1 Mutations and Risk of Female Breast Cancer: Meta-Analysis and Experimental Data

1Cancer Genetics Laboratory, Department of Biosciences, COMSATS Institute of Information Technology, Park Road, Chak Shahzad, Islamabad 44000, Pakistan
2Nuclear Medicine Oncology & Radiotherapy Institute (NORI), Islamabad 44000, Pakistan

Received 5 January 2015; Accepted 9 April 2015

Academic Editor: Holly Soares

Copyright © 2015 Kashif Ali et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

In Supplementary material, supplementary Table 1 contained the detailed information regarding the demographic characteristics of patients and controls of sampled population. Significantly increased risk of breast cancer was found associated in patients with family history of cancer and similar trend was found in case age of menopause. Supplementary Table 1 also showed that significantly higher percentage of breast cancer patients were smokers as compared to controls. Supplementary Table 2 contained the information regarding the histopathological parameters of study cohort and majority of breast cancer patients were with invasive ductal carcinoma with grade-II and negative ER, PR and HER-2/neu status. Supplementary Table 3 represents the details of mutations observed in the OGG1 gene in breast cancer patients along with possible consequences of these changes at protein level.

  1. Supplementary Materials