Research Article
Significant Association of HLA-B Alleles and Genotypes in Thai Children with Autism Spectrum Disorders: A Case-Control Study
Table 2
HLA-B allele frequency in autistic children and control group.
| HLA-B
alleles | Number of individuals (%) |
OR (95% CI) | value | ASD
Allele frequencies (%) | Control
Allele frequencies (%) |
| | B07:02 | 3 (0.41) | 19 (1.00) | 0.411 (0.121–1.391) | 0.153 | | B07:05 | 19 (2.61) | 30 (1.58) | 1.674 (0.936–2.993) | 0.082 | | B07:09 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B07:13 | 0 (0.00) | 3 (0.16) | 0.373 (0.019–7.228) | 0.514 | | B07:14 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B07:18 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B08:01 | 4 (0.55) | 11 (0.58) | 0.951 (0.302–2.996) | 0.931 | | B08:02 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B08:03 | 1 (0.14) | 1 (0.05) | 2.618 (0.164–41.906) | 0.496 | | B08:12 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B08:33 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B13:01 | 40 (5.49) | 146 (7.67) | 0.700 (0.488–1.004) | 0.527 | | B13:02 | 16 (2.20) | 19 (1.00) | 2.229 (1.140–4.359) | 0.019 | | B13:03 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B13:09 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B13:28 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B13:39 | 0 (0.00) | 2 (0.11) | 0.522 (0.025–10.893) | 0.675 | | B14:02 | 2 (0.27) | 0 (0.00) | 13.107 (0.629–273.362) | 0.097 | | B14:13 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B15:01 | 12 (1.65) | 23 (1.21) | 1.371 (0.678–2.769) | 0.379 | | B15:02 | 55 (7.55) | 160 (8.40) | 0.891 (0.648–1.226) | 0.477 | | B15:03 | 1 (0.14) | 0 (0.00) | 7.854 (0.319–193.017) | 0.207 | | B15:04 | 1 (0.14) | 5 (0.26) | 0.522 (0.061–4.479) | 0.554 | | B15:06 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B15:07 | 1 (0.14) | 3 (0.16) | 0.872 (0.091–8.393) | 0.905 | | B15:11 | 0 (0.00) | 7 (0.37) | 0.174 (0.010–3.044) | 0.231 | | B15:12 | 3 (0.41) | 7 (0.37) | 1.121 (0.289–4.348) | 0.868 | | B15:13 | 2 (0.27) | 13 (0.68) | 0.401 (0.090–1.780) | 0.229 | | B15:17 | 1 (0.14) | 10 (0.53) | 0.261 (0.034–2.039) | 0.200 | | B15:18 | 3 (0.41) | 4 (0.21) | 1.965 (0.439–8.804) | 0.377 | | B15:20 | 2 (0.27) | 0 (0.00) | 13.107 (0.629–273.362) | 0.097 | | B15:21 | 4 (0.55) | 6 (0.32) | 1.748 (0.492–6.211) | 0.388 | | B15:22 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B15:25 | 11 (1.51) | 27 (1.42) | 1.067 (0.526–2.161) | 0.858 | | B15:27 | 2 (0.27) | 2 (0.11) | 2.619 (0.368–18.634) | 0.336 | | B15:31 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B15:32 | 1 (0.14) | 8 (0.42) | 0.326 (0.041–2.601) | 0.291 | | B15:35 | 3 (0.41) | 22 (1.16) | 0.354 (0.106–1.186) | 0.092 | | B15:88 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B18:01 | 24 (3.30) | 58 (3.05) | 1.085 (0.669–1.759) | 0.741 | | B18:02 | 7 (0.96) | 48 (2.52) | 0.375 (0.169–0.836) | 0.016 | | B18:09 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B18:18 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B27:03 | 1 (0.14) | 5 (0.26) | 0.522 (0.061–4.479) | 0.554 | | B27:04 | 13 (1.79) | 37 (1.94) | 0.917 (0.485–1.736) | 0.791 | | B27:06 | 12 (1.65) | 15 (0.79) | 2.111 (0.983–4.531) | 0.055 | | B27:07 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B27:61 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B27:86 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B35:01 | 14 (1.92) | 36 (1.89) | 1.017 (0.546–1.898) | 0.957 | | B35:02 | 1 (0.14) | 2 (0.11) | 1.308 (0.118–14.449) | 0.826 | | B35:03 | 6 (0.82) | 21 (1.10) | 0.745 (0.299–1.854) | 0.527 | | B35:05 | 9 (1.24) | 39 (2.05) | 0.599 (0.288–1.242) | 0.168 | | B35:08 | 1 (0.14) | 0 (0.00) | 7.854 (0.319–193.017) | 0.207 | | B35:11 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B35:58 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B36:68 | 2 (0.27) | 0 (0.00) | 13.107 (0.629–273.362) | 0.097 | | B37:01 | 4 (0.55) | 9 (0.47) | 1.163 (0.357–3.789) | 0.802 | | B38:01 | 5 (0.69) | 4 (0.21) | 3.285 (0.879–12.267) | 0.077 | | B38:02 | 27 (3.71) | 44 (2.31) | 1.628 (1.001–2.649) | 0.049 | | B38:13 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B38:17 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B38:20 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B38:22 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B38:23 | 0 (0.00) | 4 (0.21) | 0.289 (0.016–5.391) | 0.406 | | B39:01 | 7 (0.96) | 11 (0.58) | 1.412 (0.561–3.554) | 0.463 | | B39:03 | 0 (0.00) | 3 (0.16) | 0.373 (0.019–7.228) | 0.514 | | B39:05 | 1 (0.14) | 2 (0.11) | 1.308 (0.118–14.449) | 0.826 | | B39:09 | 6 (0.82) | 13 (0.68) | 1.209 (0.458–3.192) | 0.702 | | B39:15 | 1 (0.14) | 13 (0.68) | 0.200 (0.026–1.532) | 0.121 | | B39:24 | 1 (0.14) | 6 (0.32) | 0.435 (0.052–3.621) | 0.441 | | B40:01 | 72 (9.89) | 155 (8.14) | 1.239 (0.923–1.661) | 0.153 | | B40:02 | 10 (1.37) | 24 (1.26) | 1.091 (0.519–2.293) | 0.818 | | B40:03 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B40:04 | 5 (0.69) | 4 (0.21) | 3.285 (0.879–12.267) | 0.077 | | B40:06 | 3 (0.41) | 11 (0.58) | 0.712 (0.198–2.559) | 0.603 | | B40:09 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B40:10 | 0 (0.00) | 6 (0.32) | 0.200 (0.011–3.563) | 0.274 | | B40:23 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B40:59 | 0 (0.00) | 2 (0.11) | 0.522 (0.025–10.893) | 0.675 | | B41:01 | 0 (0.00) | 2 (0.11) | 0.522 (0.025–10.893) | 0.675 | | B41:10 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B44:01 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B44:02 | 6 (0.82) | 11 (0.58) | 1.430 (0.527–3.881) | 0.482 | | B44:03 | 40 (5.49) | 65 (3.41) | 1.645 (1.099–2.463) | 0.016 | | B44:43 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B44:54 | 1 (0.14) | 0 (0.00) | 7.854 (0.319–193.017) | 0.207 | | B46:01 | 86 (11.81) | 209 (10.98) | 1.086 (0.832–1.419) | 0.543 | | B46:12 | 2 (0.27) | 35 (1.84) | 0.147 (0.035–0.613) | 0.008 | | B46:16 | 1 (0.14) | 0 (0.00) | 7.854 (0.319–193.017) | 0.207 | | B48:01 | 3 (0.41) | 7 (0.37) | 1.121 (0.289–4.348) | 0.868 | | B48:03 | 1 (0.14) | 5 (0.26) | 0.522 (0.061–4.479) | 0.554 | | B48:21 | 0 (0.00) | 3 (0.16) | 0.373 (0.019–7.228) | 0.514 | | B50:01 | 1 (0.14) | 2 (0.11) | 1.308 (0.118–14.449) | 0.826 | | B51:01 | 24 (3.30) | 68 (3.57) | 0.921 (0.573–1.478) | 0.732 | | B51:02 | 6 (0.82) | 20 (1.05) | 0.783 (0.313–1.957) | 0.600 | | B51:04 | 1 (0.14) | 6 (0.32) | 0.435 (0.052–3.621) | 0.441 | | B51:06 | 0 (0.00) | 3 (0.16) | 0.373 (0.019–7.228) | 0.514 | | B51:07 | 1 (0.14) | 0 (0.00) | 7.854 (0.319–193.017) | 0.207 | | B51:43 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B51:45 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B52:01 | 10 (1.37) | 48 (2.52) | 0.538 (0.271–1.070) | 0.077 | | B52:07 | 1 (0.14) | 0 (0.00) | 7.854 (0.319–193.017) | 0.207 | | B52:11 | 1 (0.14) | 1 (0.05) | 2.618 (0.164–41.906) | 0.496 | | B52:25 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B53:17 | 0 (0.00) | 3 (0.16) | 0.373 (0.019–7.228) | 0.514 | | B54:01 | 14 (1.92) | 26 (1.37) | 1.416 (0.735–2.728) | 0.298 | | B54:04 | 0 (0.00) | 2 (0.11) | 0.522 (0.025–10.893) | 0.675 | | B54:14 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B54:16 | 1 (0.14) | 0 (0.00) | 7.854 (0.319–193.017) | 0.207 | | B55:01 | 1 (0.14) | 9 (0.47) | 0.289 (0.037–2.290) | 0.240 | | B55:02 | 8 (1.10) | 26 (1.37) | 0.803 (0.362–1.781) | 0.588 | | B55:04 | 0 (0.00) | 2 (0.11) | 0.522 (0.025–10.893) | 0.675 | | B55:10 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B55:13 | 1 (0.14) | 0 (0.00) | 7.854 (0.319–193.017) | 0.207 | | B55:23 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B55:32 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B55:44 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B56:01 | 13 (1.79) | 7 (0.37) | 4.927 (1.958–12.399) | 1.78 × | | B56:02 | 0 (0.00) | 4 (0.21) | 0.289 (0.016–5.391) | 0.406 | | B56:03 | 0 (0.00) | 2 (0.11) | 0.522 (0.025–10.893) | 0.675 | | B56:04 | 0 (0.00) | 6 (0.32) | 0.200 (0.011–3.563) | 0.274 | | B56:12 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B56:16 | 2 (0.27) | 1 (0.05) | 5.242 (0.474–57.905) | 0.176 | | B57:01 | 16 (2.20) | 24 (1.26) | 1.760 (0.929–3.333) | 0.083 | | B57:21 | 1 (0.14) | 2 (0.11) | 1.308 (0.118–14.449) | 0.826 | | B58:01 | 65 (8.93) | 163 (8.56) | 1.047 (0.775–1.415) | 0.764 | | B58:34 | 1 (0.14) | 0 (0.00) | 7.854 (0.319–193.017) | 0.207 | | B58:42 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B67:01 | 0 (0.00) | 1 (0.05) | 0.871 (0.035–21.406) | 0.933 | | B73:01 | 1 (0.14) | 0 (0.00) | 7.854 (0.319–193.017) | 0.207 |
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Chi-square test.
OR: odds ratio; 95% CI: confidence interval. The bold font in table refers to significant association of alleles.
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