Association between Estrogen Receptor- Gene XbaI and PvuII Polymorphisms and Periodontitis Susceptibility: A Meta-Analysis

Table 2

Meta-analysis of the association between the ER- gene XbaI polymorphism and periodontitis.

Genetic model and subgroup	Case/control	Heterogeneity		Test of association			for Bon	for FDR
			(%)	OR	95% CI	for OR
X versus x
Overall	1514/1654	0.09	42.3	1.06	0.90, 1.24	0.480	0.480	0.48
CP	1238/1352	0.10	44.2	1.10	0.87, 1.40	0.417
AgP	276/302	0.16	50.5	0.85	0.50, 1.45	0.552
HWE (yes)	630/692	0.06	64.1	1.07	0.69, 1.66	0.779
Han	1274/1402	0.09	43.6	1.10	0.93, 1.30	0.267
Hui	240/252	NA	NA	0.84	0.56, 1.26	0.400
Female	382/414	0.12	45.2	1.04	0.78, 1.40	0.773
Male	316/388	0.62	0.0	0.64	0.45, 0.90	0.011
XX versus xx
Overall	485/449	0.41	3.6	1.67	1.13, 2.47	0.010	0.040	0.025
CP	413/384	0.23	26.6	1.71	1.12, 2.59	0.013
AgP	72/65	0.86	0.0	1.44	0.48, 4.31	0.514
HWE (yes)	196/224	0.19	69.0	0.79	0.36, 1.74	0.566
Han	410/375	0.56	0.0	1.87	1.23, 2.84	0.003
Hui	75/74	NA	NA	0.68	0.21, 2.26	0.533
Female	117/77	0.21	32.5	3.08	1.34, 7.09	0.008
Male	98/94	0.22	30.5	0.62	0.24, 1.60	0.326
Xx versus xx
Overall	661/777	0.01	60.9	0.72	0.51, 1.03	0.074	0.222	0.123
CP	532/632	0.01	64.0	0.75	0.50, 1.13	0.166
AgP	129/145	0.06	72.5	0.63	0.24, 1.66	0.346
HWE (yes)	304/330	0.10	57.1	1.17	0.70, 1.93	0.551
Han	546/658	0.01	65.6	0.71	0.47, 1.07	0.099
Hui	115/119	NA	NA	0.83	0.49, 1.39	0.479
Female	159/199	0.45	0.0	0.46	0.30, 0.71	0.001
Male	152/161	0.92	0.0	0.51	0.32, 0.80	0.003
XX + Xx versus xx
Overall	757/827	0.05	47.9	0.88	0.72, 1.07	0.202	0.404	0.253
CP	619/676	0.07	48.0	0.91	0.66, 1.25	0.561
AgP	138/151	0.08	68.5	0.68	0.28, 1.64	0.392
HWE (yes)	315/346	0.06	64.4	1.14	0.67, 1.95	0.638
Han	637/701	0.03	54.1	0.87	0.62, 1.21	0.409
Hui	120/126	NA	NA	0.81	0.49, 1.34	0.416
Female	191/207	0.44	0.0	0.62	0.41, 0.95	0.027
Male	158/194	0.88	0.0	0.52	0.33, 0.80	0.003
XX versus Xx + xx
Overall	757/827	0.17	30.9	2.07	1.43, 3.00	0.001	0.005	0.005
CP	619/676	0.08	47.1	2.13	1.44, 3.17	<0.001
AgP	138/151	0.85	0.0	1.67	0.58, 4.82	0.342
HWE (yes)	315/346	0.32	13.0	0.76	0.35, 1.66	0.489
Han	637/701	0.31	14.9	2.33	1.57, 3.47	<0.001
Hui	120/126	NA	NA	0.74	0.23, 2.40	0.614
Female	191/207	0.17	38.1	4.79	2.16, 10.61	<0.001
Male	158/194	0.22	30.8	0.83	0.33, 2.10	0.694

CP: chronic periodontitis, AgP: aggressive periodontitis, HWE: Hardy-Weinberg equilibrium, NA: not available, Bon: Bonferroni test, and FDR: false discovery rate.