Association between Estrogen Receptor- Gene XbaI and PvuII Polymorphisms and Periodontitis Susceptibility: A Meta-Analysis

Table 3

Meta-analysis of association between ER-α gene PvuII polymorphism and periodontitis.

Genetic model and subgroup	Case/control	Heterogeneity		Test of association			for Bon	for FDR
			(%)	OR	95% CI	for OR
P versus p
Overall	1302/1494	0.66	0.0	1.06	0.91, 1.23	0.452	0.904	0.565
CP	1026/1192	0.43	0.0	1.05	0.89, 1.25	0.549
AgP	276/302	0.77	0.0	1.08	0.78, 1.50	0.632
HWE (yes)	1084/1296	0.55	0.0	1.07	0.91, 1.26	0.428
Han	1062/1242	0.59	0.0	1.04	0.88, 1.23	0.681
Hui	240/252	NA	NA	1.17	0.82, 1.67	0.374
PP versus pp
Overall	334/431	0.96	0.0	1.01	0.75, 1.37	0.927	0.927	0.927
CP	268/348	0.88	0.0	0.98	0.70, 1.39	0.926
AgP	66/83	0.78	0.0	1.13	0.59, 2.18	0.707
HWE (yes)	257/361	0.92	0.0	1.01	0.72, 1.43	0.937
Han	286/361	0.97	0.0	0.95	0.68, 1.33	0.782
Hui	48/70	NA	NA	1.37	0.65, 2.86	0.405
Pp versus pp
Overall	523/587	0.01	61.1	1.29	0.86, 1.93	0.220	1.000	0.555
CP	415/471	<0.01	72.1	1.24	0.73, 2.13	0.430
AgP	108/116	0.94	0.00	1.41	0.82, 2.43	0.219
HWE (yes)	444/515	0.01	65.1	1.33	0.84, 2.12	0.225
Han	428/492	0.02	60.3	1.18	0.76, 1.83	0.454
Hui	95/95	NA	NA	2.18	1.17, 4.06	0.014
PP + Pp versus pp
Overall	651/747	0.05	50.4	1.23	0.88, 1.71	0.222	0.888	0.555
CP	513/596	0.02	64.4	1.20	0.78, 1.86	0.414
AgP	138/151	0.94	0.0	1.31	0.79, 2.19	0.296
HWE (yes)	542/648	0.04	55.6	1.27	0.86, 1.86	0.226
Han	531/621	0.07	49.0	1.15	0.80, 1.63	0.453
Hui	120/126	NA	NA	1.89	1.05, 3.41	0.035
PP versus Pp + pp
Overall	651/747	0.89	0.0	0.88	0.68, 1.15	0.358	1.000	0.565
CP	513/596	0.73	0.0	0.87	0.65, 1.18	0.385
AgP	138/151	0.71	0.0	0.91	0.52, 1.59	0.744
HWE (yes)	542/648	0.84	0.0	0.85	0.64, 1.15	0.299
Han	531/621	0.82	0.0	0.90	0.67, 1.21	0.499
Hui	120/126	NA	NA	0.81	0.44, 1.47	0.481

CP: chronic periodontitis, AgP: aggressive periodontitis, HWE: Hardy-Weinberg equilibrium, NA: not available, Bon: Bonferroni test, and FDR: false discovery rate.