Fatigue in Patients with Multiple Sclerosis: Is It Related to Pro- and Anti-Inflammatory Cytokines?

Table 2

Unadjusted and adjusted regression coefficients () of transformed cytokine levels with CIS20r fatigue score as outcome.

	Unadjusted; (se)	Adjusted; (se)	value	Explained; variance	Adjustment for confounding by
Pro-inflammatory cytokines
IL-1β	−2.250 (7.777)	−16.407 (10.719)	0.138	0.163	Age, type of MS, duration of MS, EDSS, DMDs
IL-2	−1.345 (6.008)	−2.676 (6.996)	0.705	0.019	Type of MS, EDSS, DMDs
IL-6	14.551 (6.748)	19.642 (7.036)	0.009	0.211	Age
IL-8	17.396 (11.875)	17.396 (11.875)	0.152	0.061	—
IL-12p70	1.074 (4.012)	−2.292 (5.383)	0.674	0.070	Age, type of MS, EDSS, DMDs
IL-17	8.067 (6.003)	9.011 (6.282)	0.161	0.064	EDSS
TNF-α	6.656 (18.071)	4.950 (18.824)	0.794	0.005	Duration of MS
IFN-γ	3.294 (5.806)	3.749 (6.261)	0.554	0.061	Age, type of MS, DMDs
Anti-inflammatory cytokines
IL-4	−11.081 (11.980)	−20.440 (15.070)	0.186	0.106	Age, duration of MS, EDSS
IL-5	−1.479 (4.556)	−4.594 (5.673)	0.425	0.092	Age, gender, type of MS, duration of MS, DMDs
IL-10	−2.225 (4.655)	−6.806 (5.995)	0.267	0.136	Age, gender, type of MS, duration of MS, EDSS, DMDs
IL-13	−2.804 (5.097)	−7.884 (6.467)	0.233	0.113	Age, type of MS, EDSS, DMDs

Significant .