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Disease Markers
Volume 2015 (2015), Article ID 762128, 10 pages
http://dx.doi.org/10.1155/2015/762128
Review Article

Omics-Based Identification of Biomarkers for Nasopharyngeal Carcinoma

Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand

Received 7 November 2014; Accepted 10 March 2015

Academic Editor: Lance A. Liotta

Copyright © 2015 Tavan Janvilisri. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Nasopharyngeal carcinoma (NPC) is a head and neck cancer that is highly found in distinct geographic areas, such as Southeast Asia. The management of NPC remains burdensome as the prognosis is poor due to the late presentation of the disease and the complex nature of NPC pathogenesis. Therefore, it is necessary to find effective molecular markers for early detection and therapeutic measure of NPC. In this paper, the discovery of molecular biomarker for NPC through the emerging omics technologies including genomics, miRNA-omics, transcriptomics, proteomics, and metabolomics will be extensively reviewed. These markers have been shown to play roles in various cellular pathways in NPC progression. The knowledge on their function will help us understand in more detail the complexity in tumor biology, leading to the better strategies for early detection, outcome prediction, detection of disease recurrence, and therapeutic approach.