Assessment of Glomerular Filtration Rate Based on Alterations of Serum Brain-Derived Neurotrophic Factor in Type 2 Diabetic Subjects Treated with Amlodipine/Benazepril or Valsartan/Hydrochlorothiazide

Table 2

Multivariate regression analysis showing an independent association between altered serum BDNF levels and altered eGFR after the study.

			95% CI
Valsartan/hydrochlorothiazide	−0.204	−5.328	(−9.633, −1.022)	0.016
ΔBDNF (ng/mL)	−0.189	−0.481	(−0.887, −0.076)	0.020
ΔBMI (kg/m^2)	0.140	2.970	(−0.287, 6.228)	0.074
Δtriglyceride (mmol/L)	0.138	1.998	(−0.375, 4.371)	0.098
ΔHbA1c (%)	−0.084	−1.281	(−3.720, 1.157)	0.301
Δplatelets (10^5/μL)	−0.059	−2.043	(−7.469, 3.383)	0.458
Δtotal cholesterol (mmol/L)	−0.051	−0.925	(−3.781, 1.931)	0.523
Δsystolic BP (10 mmHg)	−0.018	−0.196	(−1.841, 1.450)	0.814

after adjusting for the age, gender, and baseline eGFR.
¹: standardized coefficient, ²: linear regression coefficient.
Δ: variable after treatment, variable before treatment
BDNF, brain-derived neurotrophic factor; BMI, body mass index; BP, blood pressure, eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin.