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Disease Markers
Volume 2015, Article ID 786708, 6 pages
http://dx.doi.org/10.1155/2015/786708
Research Article

Serum Chemerin Levels in relation to Osteoporosis and Bone Mineral Density: A Case-Control Study

1Department of Orthopedics, Jintan Hospital, Jiangsu University, Jintan 213200, China
2College of Medicine, Zhejiang University, Hangzhou 310058, China

Received 18 May 2015; Revised 3 June 2015; Accepted 8 June 2015

Academic Editor: Robert Pichler

Copyright © 2015 Jing He et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. To evaluate serum chemerin levels in patients with osteoporosis and healthy controls and to investigate the relationship between serum chemerin levels and bone mineral density (BMD). Methods. An age- and gender-matched case-control study was conducted. Pearson’s correlation test was performed to investigate the relationship between serum chemerin levels and BMD. Results. There were 93 patients included in the osteoporosis group and 93 matched controls. Serum chemerin level was significantly higher in patients with osteoporosis ( ng/mL) than patients in control ( ng/mL) (). There was a negative correlation between femoral bone mineral density and chemerin in both groups (, in osteoporosis group; , in control) and also a negative correlation between lumbar bone mineral density with chemerin in both groups (, in osteoporosis group; , in control). Conclusions. Patients with osteoporosis presented a higher level of serum chemerin, which witnessed an inverse correlation with BMD. Further studies are needed to explore the role of chemerin in the pathophysiology of osteoporosis.