Polymorphism on Chromosome 9p21.3 Is Associated with Severity and Early-Onset CAD in Type 2 Diabetic Tunisian Population
Table 1
Baseline clinical characteristics and biochemical assessments.
Control CAD group
Total of the diabetic population
Group 1
Group 2
Group 3
101
273
138
36
100
—
Gender: male/female (%)
56,4/43,6
52,7/47,3
52,2/47,8
58,3/41,7
52/48
0,651
Age (years)
56,27 ± 16,75
62,82 ± 12,26
60,36 ± 13,42
65,92 ± 9,17
65,26 ± 10,91
0,003
Family history for CAD (%)
46,9
60,4
50,7
63,9
72
0,007
Hypertension (%)
40,1
59,3
47,8
63,9
75
<0,001
BMI
27,21 ± 3,99
29,59 ± 4,51
28,63 ± 4,74
30,03 ± 2,02
30,73 ± 4,55
0,002
Obesity (%)
30,4
47,3
35,5
61,1
58
0,001
HbA1c (mmol/L)
7,1 ± 3,52
10,52 ± 4,20
10,27 ± 3,94
10,08 ± 4,30
11,06 ± 4,50
0,251
Smoking (%)
31,9
42,1
33,3
58,3
49
0,006
Cholesterol (mmol/L)
4,58 ± 1,3
4,72 ± 1,12
4,73 ± 1,14
4,52 ± 0,87
4,78 ± 1,18
0,414
LDL (mmol/L)
2,91 ± 1,13
3,73 ± 1,45
3,28 ± 1,22
3,86 ± 1,35
4,29 ± 1,57
<0,001
HDL (mmol/L)
1,14 ± 0,44
1,23 ± 0,52
1,26 ± 0,51
1,17 ± 0,40
1,22 ± 0,58
0,455
TG (mmol/L)
1,27 ± 0,64
2,21 ± 1,29
1,76 ± 1,06
2,07 ± 0,98
2,91 ± 1,40
<0,001
Hyperlipidemia (%)
55,6
49,5
—
97,2
100
<0,001
Insulin (%)
—
52,4
36,2
61,1
72
<0,001
Rs1333049 genotypes
GG (%)
72,3
25,3
40,6
11,1
10
0,377
GC (%)
22,8
46,2
52,9
47,2
36
0,136
CC (%)
5
28,6
6,5
41,7
54
<0,001
Data are number (%) and mean ± SD. BMI: body mass index; CAD: coronary artery disease; HbA1c: glycosylated hemoglobin; HDL-C: HDL cholesterol; LDL-C: LDL cholesterol; TC: cholesterol total; TG: triglycerides.
