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Disease Markers
Volume 2015, Article ID 804739, 5 pages
Research Article

Impaired Fasting Glucose in Nondiabetic Range: Is It a Marker of Cardiovascular Risk Factor Clustering?

1División de Enfermedades Cardiovasculares, Facultad de Medicina, Escuela de Medicina, Pontificia Universidad Católica de Chile, 8330074 Santiago, Chile
2Departamento de Matemáticas, Universidad de la Serena, La Serena, Chile

Received 27 June 2015; Revised 9 September 2015; Accepted 13 September 2015

Academic Editor: Silvia Persichilli

Copyright © 2015 Giovanna Valentino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Impaired fasting glucose (IFG) through the nondiabetic range (100–125 mg/dL) is not considered in the cardiovascular (CV) risk profile. Aim. To compare the clustering of CV risk factors (RFs) in nondiabetic subjects with normal fasting glucose (NFG) and IFG. Material and Methods. Cross-sectional study in 3739 nondiabetic subjects. Demographics, medical history, and CV risk factors were collected and lipid profile, fasting glucose levels (FBG), C-reactive protein (hsCRP), blood pressure (BP), anthropometric measurements, and aerobic capacity were determined. Results. 559 (15%) subjects had IFG: they had a higher mean age, BMI, waist circumference, non-HDL cholesterol, BP, and hsCRP () and lower HDL () and aerobic capacity (). They also had a higher prevalence of hypertension (34% versus 25%; ), dyslipidemia (79% versus 74%; ), and obesity (29% versus 16%; ) and a higher Framingham risk score (8% versus 6%; ). The probability of presenting 3 or more CV RFs adjusted by age and gender was significantly higher in the top quintile of fasting glucose (≥98 mg/dL; OR = 2.02; 1.62–2.51). Conclusions. IFG in the nondiabetic range is associated with increased cardiovascular RF clustering.