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Disease Markers
Volume 2015 (2015), Article ID 824624, 12 pages
http://dx.doi.org/10.1155/2015/824624
Review Article

The Prognostic Role of Red Blood Cell Distribution Width in Coronary Artery Disease: A Review of the Pathophysiology

3rd Department of Cardiology, SMDZ in Zabrze, Medical University of Silesia, Marii Skłodowskiej Curie Street 9, 41-800 Zabrze, Poland

Received 18 June 2015; Revised 14 August 2015; Accepted 18 August 2015

Academic Editor: Shih-Ping Hsu

Copyright © 2015 Kamil Bujak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Karnad and T. R. Poskitt, “The automated complete blood cell count. Use of the red blood cell volume distribution width and mean platelet volume in evaluating anemia and thrombocytopenia,” Archives of Internal Medicine, vol. 145, no. 7, pp. 1270–1272, 1985. View at Publisher · View at Google Scholar · View at Scopus
  2. G. M. Felker, L. A. Allen, S. J. Pocock et al., “Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM program and the duke databank,” Journal of the American College of Cardiology, vol. 50, no. 1, pp. 40–47, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. K. V. Patel, R. D. Semba, L. Ferrucci et al., “Red cell distribution width and mortality in older adults: a meta-analysis,” Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol. 65, no. 3, pp. 258–265, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. Z. Ye, C. Smith, and I. J. Kullo, “Usefulness of red cell distribution width to predict mortality in patients with peripheral artery disease,” The American Journal of Cardiology, vol. 107, no. 8, pp. 1241–1245, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. E. C. Seyhan, M. A. Ozgül, N. Tutar, I. Omür, A. Uysal, and S. Altin, “Red Blood Cell Distribution and Survival in Patients with Chronic Obstructive Pulmonary Disease,” Journal of Chronic Obstructive Pulmonary Disease, vol. 10, no. 4, pp. 416–424, 2013. View at Publisher · View at Google Scholar
  6. G. Lippi, G. Targher, M. Montagnana, G. L. Salvagno, G. Zoppini, and G. C. Guidi, “Relationship between red blood cell distribution width and kidney function tests in a large cohort of unselected outpatients,” Scandinavian Journal of Clinical and Laboratory Investigation, vol. 68, no. 8, pp. 745–748, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. Z.-Z. Li, L. Chen, H. Yuan, T. Zhou, and Z.-M. Kuang, “Relationship between red blood cell distribution width and early-stage renal function damage in patients with essential hypertension,” Journal of Hypertension, vol. 32, pp. 2450–2456, 2014. View at Google Scholar
  8. M. Zhang, Y. Zhang, C. Li, and L. He, “Association between red blood cell distribution and renal function in patients with untreated type 2 diabetes mellitus,” Renal Failure, vol. 37, no. 4, pp. 659–663, 2015. View at Publisher · View at Google Scholar
  9. M. Tonelli, F. Sacks, M. Arnold, L. Moye, B. Davis, and M. Pfeffer, “Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease,” Circulation, vol. 117, no. 2, pp. 163–168, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. T. Osadnik, J. Strzelczyk, M. Hawranek et al., “Red cell distribution width is associated with long-term prognosis in patients with stable coronary artery disease,” BMC Cardiovascular Disorders, vol. 13, article 113, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. M. B. Sangoi, N. D. S. Guarda, A. P. P. Rödel et al., “Prognostic value of red blood cell distribution width in prediction of in-hospital mortality in patients with acute myocardial infarction,” Clinical Laboratory, vol. 60, no. 8, pp. 1351–1356, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. X.-P. Sun, W.-M. Chen, Z.-J. Sun et al., “Impact of red blood cell distribution width on long-term mortality in patients with st-elevation myocardial infarction,” Cardiology, vol. 128, no. 4, pp. 343–348, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Poludasu, J. D. Marmur, J. Weedon, W. Khan, and E. Cavusoglu, “Red cell distribution width (RDW) as a predictor of long-term mortality in patients undergoing percutaneous coronary intervention,” Thrombosis and Haemostasis, vol. 102, no. 3, pp. 581–587, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Nabais, N. Losa, A. Gaspar et al., “Association between red blood cell distribution width and outcomes at six months in patients with acute coronary syndromes,” Revista Portuguesa de Cardiologia, vol. 28, no. 9, pp. 905–924, 2009. View at Google Scholar · View at Scopus
  15. S. Dabbah, H. Hammerman, W. Markiewicz, and D. Aronson, “Relation between red cell distribution width and clinical outcomes after acute myocardial infarction,” American Journal of Cardiology, vol. 105, no. 3, pp. 312–317, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. E. Cavusoglu, V. Chopra, A. Gupta et al., “Relation between red blood cell distribution width (RDW) and all-cause mortality at two years in an unselected population referred for coronary angiography,” International Journal of Cardiology, vol. 141, no. 2, pp. 141–146, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. Y.-L. Wang, Q. Hua, C.-R. Bai, and Q. Tang, “Relationship between red cell distribution width and short-term outcomes in acute coronary syndrome in a Chinese population,” Internal Medicine, vol. 50, no. 24, pp. 2941–2945, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. B. Azab, E. Torbey, H. Hatoum et al., “Usefulness of red cell distribution width in predicting all-cause long-term mortality after non-ST-elevation myocardial infarction,” Cardiology, vol. 119, no. 2, pp. 72–80, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Uyarel, M. Ergelen, G. Cicek et al., “Red cell distribution width as a novel prognostic marker in patients undergoing primary angioplasty for acute myocardial infarction,” Coronary Artery Disease, vol. 22, no. 3, pp. 138–144, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. J. M. Lappé, B. D. Horne, S. H. Shah et al., “Red cell distribution width, C-reactive protein, the complete blood count, and mortality in patients with coronary disease and a normal comparison population,” Clinica Chimica Acta, vol. 412, no. 23-24, pp. 2094–2099, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Vaya, J. L. Hernández, E. Zorio, and D. Bautista, “Association between red blood cell distribution width and the risk of future cardiovascular events,” Clinical Hemorheology and Microcirculation, vol. 50, no. 3, pp. 221–225, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Gul, H. Uyarel, M. Ergelen et al., “The relationship between red blood cell distribution width and the clinical outcomes in non-ST elevation myocardial infarction and unstable angina pectoris: a 3-year follow-up,” Coronary Artery Disease, vol. 23, no. 5, pp. 330–336, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. E. İlhan, T. S. Güvenç, S. Altay et al., “Predictive value of red cell distribution width in intrahospital mortality and postintervention thrombolysis in myocardial infarction flow in patients with acute anterior myocardial infarction,” Coronary Artery Disease, vol. 23, no. 7, pp. 450–454, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. O. Fatemi, J. Paranilam, A. Rainow et al., “Red cell distribution width is a predictor of mortality in patients undergoing percutaneous coronary intervention,” Journal of Thrombosis and Thrombolysis, vol. 35, no. 1, pp. 57–64, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Tsuboi, K. Miyauchi, T. Kasai et al., “Impact of red blood cell distribution width on long-term mortality in diabetic patients after percutaneous coronary intervention,” Circulation Journal, vol. 77, no. 2, pp. 456–461, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. R. Warwick, N. Mediratta, M. Shaw et al., “Red cell distribution width and coronary artery bypass surgery,” European Journal of Cardio-Thoracic Surgery, vol. 43, no. 6, pp. 1165–1169, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. J. H. Lee, D. H. Yang, S. Y. Jang et al., “Incremental predictive value of red cell distribution width for 12-month clinical outcome after acute myocardial infarction,” Clinical Cardiology, vol. 36, no. 6, pp. 336–341, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Ren, Q. Hua, M. Quan et al., “Relationship between the red cell distribution width and the one-year outcomes in Chinese patients with stable angina pectoris,” Internal Medicine, vol. 52, no. 16, pp. 1769–1774, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. H.-M. Yao, T.-W. Sun, X.-J. Zhang et al., “Red blood cell distribution width and long-term outcome in patients undergoing percutaneous coronary intervention in the drug-eluting stenting era: a two-year cohort study,” PLoS ONE, vol. 9, no. 4, Article ID e94887, 2014. View at Publisher · View at Google Scholar
  30. C. Vieira, S. Nabais, V. Ramos et al., “Multimarker approach with cystatin C, N-terminal pro-brain natriuretic peptide, C-reactive protein and red blood cell distribution width in risk stratification of patients with acute coronary syndromes,” Revista Portuguesa de Cardiologia, vol. 33, no. 3, pp. 127–136, 2014. View at Publisher · View at Google Scholar · View at Scopus
  31. Y. Arbel, E. Y. Birati, A. Finkelstein et al., “Red blood cell distribution width and 3-year outcome in patients undergoing cardiac catheterization,” Journal of Thrombosis and Thrombolysis, vol. 37, no. 4, pp. 469–474, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. Y. Arbel, Y. Shacham, A. Finkelstein et al., “Red blood cell distribution width (RDW) and long-term survival in patients with ST elevation myocardial infarction,” Thrombosis Research, vol. 134, no. 5, pp. 976–979, 2014. View at Publisher · View at Google Scholar
  33. A. Bekler, E. Tenekecioğlu, G. Erbağ et al., “Relationship between red cell distribution width and long-term mortality in patients with non-ST elevation acute coronary syndrome,” The Anatolian Journal of Cardiology, 2015. View at Publisher · View at Google Scholar
  34. X.-M. Liu, C.-S. Ma, X.-H. Liu et al., “Relationship between red blood cell distribution width and intermediate-term mortality in elderly patients after percutaneous coronary intervention,” Journal of Geriatric Cardiology, vol. 12, no. 1, pp. 17–22, 2015. View at Publisher · View at Google Scholar · View at Scopus
  35. A. T. Timoteo, A. L. Papoila, A. Lousinha et al., “Predictive impact on mediumterm mortality of hematological parameters in Acute Coronary Syndromes: added value on top of GRACE risk score,” European Heart Journal: Acute Cardiovascular Care, vol. 4, no. 2, pp. 172–179, 2015. View at Publisher · View at Google Scholar
  36. G. Lippi, L. Filippozzi, M. Montagnana et al., “Clinical usefulness of measuring red blood cell distribution width on admission in patients with acute coronary syndromes,” Clinical Chemistry and Laboratory Medicine, vol. 47, no. 3, pp. 353–357, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. G. Ephrem and Y. Kanei, “Elevated red blood cell distribution width is associated with higher recourse to coronary artery bypass graft,” Cardiology, vol. 123, no. 3, pp. 135–141, 2012. View at Publisher · View at Google Scholar · View at Scopus
  38. O. K. Uysal, M. Duran, B. Ozkan et al., “Red cell distribution width is associated with acute myocardial infarction in young patients,” Cardiology Journal, vol. 19, no. 6, pp. 597–602, 2012. View at Publisher · View at Google Scholar · View at Scopus
  39. T. Isik, H. Uyarel, I. H. Tanboga et al., “Relation of red cell distribution width with the presence, severity, and complexity of coronary artery disease,” Coronary Artery Disease, vol. 23, no. 1, pp. 51–56, 2012. View at Publisher · View at Google Scholar · View at Scopus
  40. F.-L. Ma, S. Li, X.-L. Li et al., “Correlation of red cell distribution width with the severity of coronary artery disease: a large Chinese cohort study from a single center,” Chinese Medical Journal, vol. 126, no. 6, pp. 1053–1057, 2013. View at Publisher · View at Google Scholar · View at Scopus
  41. G. Ephrem, “Red blood cell distribution width is a predictor of readmission in cardiac patients,” Clinical Cardiology, vol. 36, no. 5, pp. 293–299, 2013. View at Publisher · View at Google Scholar · View at Scopus
  42. M. Duran, O. K. Uysal, O. Günebakmaz et al., “Increased red cell distribution width level is associated with absence of coronary collateral vessels in patients with acute coronary syndromes,” Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin yayın Organıdır, vol. 41, no. 5, pp. 399–405, 2013. View at Publisher · View at Google Scholar
  43. F. Akin, N. Köse, B. Ayça et al., “Relation between red cell distribution width and severity of coronary artery disease in patients with acute myocardial infarction,” Angiology, vol. 64, no. 8, pp. 592–596, 2013. View at Publisher · View at Google Scholar · View at Scopus
  44. I. H. Tanboga, S. Topcu, E. Aksakal, K. Kalkan, S. Sevimli, and M. Acikel, “Determinants of angiographic thrombus burden in patients with ST-segment elevation myocardial infarction,” Clinical and Applied Thrombosis/Hemostasis, vol. 20, pp. 716–722, 2014. View at Google Scholar
  45. H. Akilli, M. Kayrak, A. Aribas et al., “The relationship between red blood cell distribution width and myocardial ischemia in dobutamine stress echocardiography,” Coronary Artery Disease, vol. 25, no. 2, pp. 152–158, 2014. View at Publisher · View at Google Scholar · View at Scopus
  46. A. Bekler, E. Gazi, E. Tenekecioglu et al., “Assessment of the relationship between red cell distribution width and fragmented QRS in patients with non-ST elevated acute coronary syndrome,” Medical Science Monitor, vol. 20, pp. 413–419, 2014. View at Publisher · View at Google Scholar · View at Scopus
  47. I. H. Tanboga, S. Topcu, T. Nacar et al., “Relation of coronary collateral circulation with red cell distribution width in patients with non-ST elevation myocardial infarction,” Clinical and Applied Thrombosis/Hemostasis, vol. 20, no. 4, pp. 411–415, 2014. View at Publisher · View at Google Scholar · View at Scopus
  48. H. Acet, F. Erta , M. A. Ak l et al., “Relationship between hematologic indices and global registry of acute coronary events risk score in patients with ST-segment elevation myocardial infarction,” Clinical and Applied Thrombosis/Hemostasis, 2014. View at Publisher · View at Google Scholar
  49. N. Polat, A. Yildiz, M. Oylumlu et al., “Relationship between red cell distribution width and the GRACE risk score with in-hospital death in patients with acute coronary syndrome,” Clinical and Applied Thrombosis/Hemostasis, vol. 20, no. 6, pp. 577–582, 2014. View at Publisher · View at Google Scholar · View at Scopus
  50. P. Wang, Y. Wang, H. Li, Y. Wu, and H. Chen, “Relationship between the red blood cell distribution width and risk of acute myocardial infarction,” Journal of Atherosclerosis and Thrombosis, vol. 22, no. 1, pp. 21–26, 2015. View at Publisher · View at Google Scholar · View at Scopus
  51. İ. Şahin, A. Karabulut, A. Kaya et al., “Increased level of red cell distribution width is associated with poor coronary collateral circulation in patients with stable coronary artery disease,” Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin yayın Organıdır, vol. 43, no. 2, pp. 123–130, 2015. View at Publisher · View at Google Scholar
  52. E. Baysal, M. Çetin, B. Yaylak et al., “Roles of the red cell distribution width and neutrophil/lymphocyte ratio in predicting thrombolysis failure in patients with an ST-segment elevation myocardial infarction,” Blood Coagulation and Fibrinolysis, vol. 26, pp. 274–278, 2015. View at Publisher · View at Google Scholar · View at Scopus
  53. Y. Li, Q. Xiao, W. Zeng et al., “Red blood cell distribution width is independently correlated with diurnal QTc variation in patients with coronary heart disease,” Medicine, vol. 94, no. 23, p. e822, 2015. View at Publisher · View at Google Scholar
  54. W. Li, X. Li, M. Wang et al., “Association between red cell distribution width and the risk of heart events in patients with coronary artery disease,” Experimental and Therapeutic Medicine, vol. 9, no. 4, pp. 1508–1514, 2015. View at Publisher · View at Google Scholar · View at Scopus
  55. O. Sahin, M. Akpek, B. Sarli et al., “Association of red blood cell distribution width levels with severity of coronary artery disease in patients with non-st elevation myocardial infarction,” Medical Principles and Practice, vol. 24, no. 2, 2015. View at Publisher · View at Google Scholar · View at Scopus
  56. A. Karabulut, H. Uyarel, B. Uzunlar, and M. Çakmak, “Elevated red cell distribution width level predicts worse postinterventional thrombolysis in myocardial infarction flow reflecting abnormal reperfusion in acute myocardial infarction treated with a primary coronary intervention,” Coronary Artery Disease, vol. 23, no. 1, pp. 68–72, 2012. View at Publisher · View at Google Scholar · View at Scopus
  57. T. Isik, M. Kurt, E. Ayhan, I. H. Tanboga, M. Ergelen, and H. Uyarel, “The impact of admission red cell distribution width on the development of poor myocardial perfusion after primary percutaneous intervention,” Atherosclerosis, vol. 224, no. 1, pp. 143–149, 2012. View at Publisher · View at Google Scholar · View at Scopus
  58. A. Akyel, I. E. Çelik, F. Öksüz et al., “Red blood cell distribution width in saphenous vein graft disease,” Canadian Journal of Cardiology, vol. 29, no. 4, pp. 448–451, 2013. View at Publisher · View at Google Scholar · View at Scopus
  59. G. Ertaş, C. Aydin, O. Sönmez et al., “Red cell distribution width predicts new-onset atrial fibrillation after coronary artery bypass grafting,” Scandinavian Cardiovascular Journal, vol. 47, no. 3, pp. 132–135, 2013. View at Publisher · View at Google Scholar · View at Scopus
  60. O. Fatemi, R. Torguson, F. Chen et al., “Red cell distribution width as a bleeding predictor after percutaneous coronary intervention,” The American Heart Journal, vol. 166, no. 1, pp. 104–109, 2013. View at Publisher · View at Google Scholar · View at Scopus
  61. A. Yildiz, F. Tekiner, A. Karakurt, G. Sirin, and D. Duman, “Preprocedural red blood cell distribution width predicts bare metal stent restenosis,” Coronary Artery Disease, vol. 25, no. 6, pp. 469–473, 2014. View at Publisher · View at Google Scholar · View at Scopus
  62. A. Kurtul, M. Yarlioglues, S. N. Murat et al., “Red cell distribution width predicts contrast-induced nephropathy in patients undergoing percutaneous coronary intervention for acute coronary syndrome,” Angiology, vol. 66, pp. 433–440, 2015. View at Google Scholar
  63. A. Kurtul, S. N. Murat, M. Yarlioglues et al., “The association of red cell distribution width with in-stent restenosis in patients with stable coronary artery disease,” Platelets, vol. 26, no. 1, pp. 48–52, 2015. View at Publisher · View at Google Scholar · View at Scopus
  64. K. Zhao, Y.-J. Li, and S. Gao, “Role of red blood cell distribution in predicting drug-eluting stent restenosis in patients with stable angina pectoris after coronary stenting,” Coronary Artery Disease, vol. 26, pp. 220–224, 2015. View at Publisher · View at Google Scholar · View at Scopus
  65. F. Akin, O. Celik, I. Altun et al., “Relation of red cell distribution width to contrast-induced acute kidney injury in patients undergoing a primary percutaneous coronary intervention,” Coronary Artery Disease, vol. 26, no. 4, pp. 289–295, 2015. View at Publisher · View at Google Scholar
  66. A. Mizuno, S. Ohde, Y. Nishizaki, Y. Komatsu, and K. Niwa, “Additional value of the red blood cell distribution width to the Mehran risk score for predicting contrast-induced acute kidney injury in patients with ST-elevation acute myocardial infarction,” Journal of Cardiology, vol. 66, no. 1, pp. 41–45, 2015. View at Publisher · View at Google Scholar
  67. V. Veeranna, S. K. Zalawadiya, S. Panaich, K. V. Patel, and L. Afonso, “Comparative analysis of red cell distribution width and high sensitivity C-reactive protein for coronary heart disease mortality prediction in multi-ethnic population: findings from the 1999–2004 NHANES,” International Journal of Cardiology, vol. 168, no. 6, pp. 5156–5161, 2013. View at Publisher · View at Google Scholar · View at Scopus
  68. Y. Borné, J. G. Smith, O. Melander, and G. Engström, “Red cell distribution width in relation to incidence of coronary events and case fatality rates: a population-based cohort study,” Heart, vol. 100, no. 14, pp. 1119–1124, 2014. View at Publisher · View at Google Scholar · View at Scopus
  69. T. Skjelbakken, J. Lappegard, T. S. Ellingsen et al., “Red cell distribution width is associated with incident myocardial infarction in a general population: the Tromsø study,” Journal of the American Heart Association, vol. 3, no. 4, Article ID e001109, 2014. View at Publisher · View at Google Scholar
  70. T. Osadnik, J. Strzelczyk, K. Bujak et al., “Functional polymorphism rs710218 in the gene coding GLUT1 protein is associated with in-stent restenosis,” Biomarkers in Medicine, 2015. View at Publisher · View at Google Scholar
  71. W. He, J. Jia, J. Chen et al., “Comparison of prognostic value of red cell distribution width and NT-proBNP for short-term clinical outcomes in acute heart failure patients,” International Heart Journal, vol. 55, no. 1, pp. 58–64, 2014. View at Publisher · View at Google Scholar · View at Scopus
  72. E. Sertoglu, S. Tapan, and M. Uyanik, “Important details about the red cell distribution width,” Journal of Atherosclerosis and Thrombosis, vol. 22, no. 2, pp. 219–220, 2015. View at Publisher · View at Google Scholar · View at Scopus
  73. Z. Förhécz, T. Gombos, G. Borgulya, Z. Pozsonyi, Z. Prohászka, and L. Jánoskuti, “Red cell distribution width in heart failure: prediction of clinical events and relationship with markers of ineffective erythropoiesis, inflammation, renal function, and nutritional state,” American Heart Journal, vol. 158, no. 4, pp. 659–666, 2009. View at Publisher · View at Google Scholar · View at Scopus
  74. S. Muzzarelli and M. Pfisterer, “Anemia as independent predictor of major events in elderly patients with chronic angina,” American Heart Journal, vol. 152, no. 5, pp. 991–996, 2006. View at Publisher · View at Google Scholar · View at Scopus
  75. N. Aung, H. Z. Ling, A. S. Cheng et al., “Expansion of the red cell distribution width and evolving iron deficiency as predictors of poor outcome in chronic heart failure,” International Journal of Cardiology, vol. 168, no. 3, pp. 1997–2002, 2013. View at Publisher · View at Google Scholar · View at Scopus
  76. A. C. Salisbury, A. P. Amin, K. J. Reid et al., “Red blood cell indices and development of hospital-acquired anemia during acute myocardial infarction,” American Journal of Cardiology, vol. 109, no. 8, pp. 1104–1110, 2012. View at Publisher · View at Google Scholar · View at Scopus
  77. T. B. Grammer, M. E. Kleber, G. Silbernagel et al., “Hemoglobin, iron metabolism and angiographic coronary artery disease (The Ludwigshafen Risk and Cardiovascular Health Study),” Atherosclerosis, vol. 236, no. 2, pp. 292–300, 2014. View at Publisher · View at Google Scholar · View at Scopus
  78. B. Ponikowska, T. Suchocki, B. Paleczny et al., “Iron status and survival in diabetic patients with coronary artery disease,” Diabetes Care, vol. 36, no. 12, pp. 4147–4156, 2013. View at Publisher · View at Google Scholar · View at Scopus
  79. G. Lippi, F. Sanchis-Gomar, E. Danese, and M. Montagnana, “Association of red blood cell distribution width with plasma lipids in a general population of unselected outpatients,” Kardiologia Polska, vol. 71, no. 9, pp. 931–936, 2013. View at Publisher · View at Google Scholar · View at Scopus
  80. M. Kucera, D. Balaz, P. Kruzliak et al., “The effects of atorvastatin treatment on the mean platelet volume and red cell distribution width in patients with dyslipoproteinemia and comparison with plasma atherogenicity indicators—a pilot study,” Clinical Biochemistry, vol. 48, no. 9, pp. 557–561, 2015. View at Publisher · View at Google Scholar
  81. D. Tziakas, G. Chalikias, A. Grapsa, T. Gioka, I. Tentes, and S. Konstantinides, “Red blood cell distribution width—a strong prognostic marker in cardiovascular disease—is associated with cholesterol content of erythrocyte membrane,” Clinical Hemorheology and Microcirculation, vol. 51, no. 4, pp. 243–254, 2012. View at Publisher · View at Google Scholar · View at Scopus
  82. J. Stuart and G. B. Nash, “Red cell deformability and haematological disorders,” Blood Reviews, vol. 4, no. 3, pp. 141–147, 1990. View at Publisher · View at Google Scholar · View at Scopus
  83. A. Vayá, A. Sarnago, O. Fuster, R. Alis, and M. Romagnoli, “Influence of inflammatory and lipidic parameters on red blood cell distribution width in a healthy population,” Clinical Hemorheology and Microcirculation, vol. 59, no. 4, pp. 379–385, 2015. View at Publisher · View at Google Scholar
  84. J. Egberts, M. R. Hardeman, and L. M. Luykx, “Decreased deformability of donor red blood cells after intrauterine transfusion in the human fetus: possible reason for their reduced life span?” Transfusion, vol. 44, no. 8, pp. 1231–1237, 2004. View at Publisher · View at Google Scholar · View at Scopus
  85. D. N. Tziakas, J. C. Kaski, G. K. Chalikias et al., “Total cholesterol content of erythrocyte membranes is increased in patients with acute coronary syndrome: a new marker of clinical instability?” Journal of the American College of Cardiology, vol. 49, no. 21, pp. 2081–2089, 2007. View at Publisher · View at Google Scholar · View at Scopus
  86. M.-M. Yu, Y. Xu, J.-H. Zhang et al., “Total cholesterol content of erythrocyte membranes levels are associated with the presence of acute coronary syndrome and high sensitivity C-reactive protein,” International Journal of Cardiology, vol. 145, no. 1, pp. 57–58, 2010. View at Publisher · View at Google Scholar · View at Scopus
  87. J. Zhang, K. Tu, Y. Xu et al., “Sphingomyelin in erythrocyte membranes increases the total cholesterol content of erythrocyte membranes in patients with acute coronary syndrome,” Coronary Artery Disease, vol. 24, no. 5, pp. 361–367, 2013. View at Publisher · View at Google Scholar · View at Scopus
  88. M. Ercan, D. Konukoğlu, T. Erdem, and S. Onen, “The effects of cholesterol levels on hemorheological parameters in diabetic patients,” Clinical Hemorheology and Microcirculation, vol. 26, no. 4, pp. 257–263, 2002. View at Google Scholar
  89. K. V. Patel, J. G. Mohanty, B. Kanapuru, C. Hesdorffer, W. B. Ershler, and J. M. Rifkind, “Association of the red cell distribution width with red blood cell deformability,” Advances in Experimental Medicine and Biology, vol. 765, pp. 211–216, 2013. View at Google Scholar · View at Scopus
  90. A. Toth, J. Papp, M. Rabai et al., “The role of hemorheological factors in cardiovascular medicine,” Clinical Hemorheology and Microcirculation, vol. 56, no. 3, pp. 197–204, 2014. View at Publisher · View at Google Scholar · View at Scopus
  91. I. Akpinar, M. R. Sayin, Y. C. Gursoy et al., “Plateletcrit and red cell distribution width are independent predictors of the slow coronary flow phenomenon,” Journal of Cardiology, vol. 63, no. 2, pp. 112–118, 2014. View at Publisher · View at Google Scholar · View at Scopus
  92. M. Kohno, K.-I. Murakawa, K. Yasunari et al., “Improvement of erythrocyte deformability by cholesterol-lowering therapy with pravastatin in hypercholesterolemic patients,” Metabolism: Clinical and Experimental, vol. 46, no. 3, pp. 287–291, 1997. View at Publisher · View at Google Scholar · View at Scopus
  93. P. Miossec, F. Zkhiri, J. Pariès, M. David-Dufilho, M. A. Devynck, and P. E. Valensi, “Effect of pravastatin on erythrocyte rheological and biochemical properties in poorly controlled Type 2 diabetic patients,” Diabetic Medicine, vol. 16, no. 5, pp. 424–430, 1999. View at Publisher · View at Google Scholar · View at Scopus
  94. R. S. Franco, “Measurement of red cell lifespan and aging,” Transfusion Medicine and Hemotherapy, vol. 39, no. 5, pp. 302–307, 2012. View at Publisher · View at Google Scholar · View at Scopus
  95. A. Owczarek, M. Babińska, B. Szyguła-Jurkiewicz, and J. Chudek, “Chronic inflammation in patients with acute coronary syndrome and chronic kidney disease,” Kardiologia Polska, vol. 69, no. 4, pp. 388–393, 2011. View at Google Scholar · View at Scopus
  96. B. Hudzik, J. Szkodzinski, J. Gorol et al., “Platelet-to-lymphocyte ratio is a marker of poor prognosis in patients with diabetes mellitus and ST-elevation myocardial infarction,” Biomarkers in Medicine, vol. 9, no. 3, pp. 199–207, 2015. View at Publisher · View at Google Scholar
  97. G. Lippi, G. Targher, M. Montagnana, G. L. Salvagno, G. Zoppini, and G. C. Guidi, “Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients,” Archives of Pathology and Laboratory Medicine, vol. 133, no. 4, pp. 628–632, 2009. View at Google Scholar · View at Scopus
  98. M. E. Emans, K. Van Der Putten, K. L. Van Rooijen et al., “Determinants of Red Cell Distribution Width (RDW) in cardiorenal patients: RDW is not related to erythropoietin resistance,” Journal of Cardiac Failure, vol. 17, no. 8, pp. 626–633, 2011. View at Publisher · View at Google Scholar · View at Scopus
  99. A. M. Konijn, “5 Iron metabolism in inflammation,” Baillière's Clinical Haematology, vol. 7, no. 4, pp. 829–849, 1994. View at Publisher · View at Google Scholar · View at Scopus
  100. C. N. Pierce and D. F. Larson, “Inflammatory cytokine inhibition of erythropoiesis in patients implanted with a mechanical circulatory assist device,” Perfusion, vol. 20, no. 2, pp. 83–90, 2005. View at Publisher · View at Google Scholar · View at Scopus
  101. V. Veeranna, S. K. Zalawadiya, S. S. Panaich, K. Ramesh, and L. Afonso, “The association of red cell distribution width with glycated hemoglobin among healthy adults without diabetes mellitus,” Cardiology, vol. 122, no. 2, pp. 129–132, 2012. View at Publisher · View at Google Scholar · View at Scopus
  102. G. Lippi, G. Targher, G. L. Salvagno, and G. C. Guidi, “Increased red blood cell distribution width (RDW) is associated with higher glycosylated hemoglobin (HbAlc) in the elderly,” Clinical Laboratory, vol. 60, no. 12, pp. 2095–2098, 2014. View at Publisher · View at Google Scholar · View at Scopus
  103. C. J. Magri and S. Fava, “Red blood cell distribution width and diabetes-associated complications,” Diabetes and Metabolic Syndrome, vol. 8, no. 1, pp. 13–17, 2014. View at Publisher · View at Google Scholar · View at Scopus
  104. N. Malandrino, W. C. Wu, T. H. Taveira, H. B. Whitlatch, and R. J. Smith, “Association between red blood cell distribution width and macrovascular and microvascular complications in diabetes,” Diabetologia, vol. 55, no. 1, pp. 226–235, 2012. View at Publisher · View at Google Scholar · View at Scopus
  105. N. Garg, N. Moorthy, A. Kapoor et al., “Hemoglobin A(1c) in nondiabetic patients: an independent predictor of coronary artery disease and its severity,” Mayo Clinic Proceedings, vol. 89, pp. 908–916, 2014. View at Google Scholar
  106. V. Kunadian, G. A. Ford, B. Bawamia, W. Qiu, and J. E. Manson, “Vitamin D deficiency and coronary artery disease: a review of the evidence,” The American Heart Journal, vol. 167, no. 3, pp. 283–291, 2014. View at Publisher · View at Google Scholar · View at Scopus
  107. J. J. Sim, P. T. Lac, I. L. A. Liu et al., “Vitamin D deficiency and anemia: a cross-sectional study,” Annals of Hematology, vol. 89, no. 5, pp. 447–452, 2010. View at Publisher · View at Google Scholar · View at Scopus
  108. P. H. A. Bours, J. P. M. Wielders, J. R. Vermeijden, and A. van de Wiel, “Seasonal variation of serum 25-hydroxyvitamin D levels in adult patients with inflammatory bowel disease,” Osteoporosis International, vol. 22, no. 11, pp. 2857–2867, 2011. View at Publisher · View at Google Scholar · View at Scopus
  109. J. S. Friedman, M. F. Lopez, M. D. Fleming et al., “SOD2-deficiency anemia: protein oxidation and altered protein expression reveal targets of damage, stress response, and antioxidant responsiveness,” Blood, vol. 104, no. 8, pp. 2565–2573, 2004. View at Publisher · View at Google Scholar · View at Scopus
  110. P.-Y. Zhang, X. Xu, and X.-C. Li, “Cardiovascular diseases: oxidative damage and antioxidant protection,” European Review for Medical and Pharmacological Sciences, vol. 18, pp. 3091–3096, 2014. View at Google Scholar
  111. S. Kobayashi, H. Moriya, K. Aso, and T. Ohtake, “Vitamin E-bonded hemodialyzer improves atherosclerosis associated with a rheological improvement of circulating red blood cells,” Kidney International, vol. 63, no. 5, pp. 1881–1887, 2003. View at Publisher · View at Google Scholar · View at Scopus
  112. T. Osadnik, J. Wasilewski, A. Lekston et al., “Comparison of modification of diet in renal disease and chronic kidney disease epidemiology collaboration formulas in predicting long-term outcomes in patients undergoing stent implantation due to stable coronary artery disease,” Clinical Research in Cardiology, vol. 103, no. 7, pp. 569–576, 2014. View at Publisher · View at Google Scholar · View at Scopus
  113. A. Parikh, H. S. Chase, L. Vernocchi, and L. Stern, “Vitamin D resistance in chronic kidney disease (CKD),” BMC Nephrology, vol. 15, no. 1, article 47, 2014. View at Publisher · View at Google Scholar · View at Scopus
  114. B. Afsar, M. Saglam, C. Yuceturk, and E. Agca, “The relationship between red cell distribution width with erythropoietin resistance in iron replete hemodialysis patients,” European Journal of Internal Medicine, vol. 24, no. 3, pp. e25–e29, 2013. View at Publisher · View at Google Scholar · View at Scopus