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Disease Markers
Volume 2015, Article ID 828145, 11 pages
http://dx.doi.org/10.1155/2015/828145
Research Article

Identification of Differentially Expressed Genes Associated with Prognosis of B Acute Lymphoblastic Leukemia

1Departamento de Bioquimica y Medicina Molecular, Facultad de Medicina, Universidad Autonoma de Nuevo Leon, Avenida F. I. Madero, S/N, Col. Mitras Centro, 64460 Monterrey, NL, Mexico
2Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de la Salud, Universidad Autonoma de Zacatecas, Carretera Zacatecas-Guadalajara Km 6, 98160 Ejido la Escondida, ZAC, Mexico
3Servicio de Hematologia, Hospital Universitario “Jose Eleuterio Gonzalez”, Universidad Autonoma de Nuevo Leon, Avenida F. I. Madero, S/N, Col. Mitras Centro, 64460 Monterrey, NL, Mexico
4Instituto Nacional de Medicina Genomica (INMEGEN), Periferico Sur No. 4809, Col. Arenal Tepepan, Delegacion Tlalpan, 14610 Mexico, DF, Mexico
5Mesoamerican Center of Public Health Studies and Disasters (CEMESAD), Universidad Autonoma de Chiapas (UNACH), Avenida Pista Principal esq Pista Secundaria, S/N, 30798 Tapachula, CHIS, Mexico
6Centro de Investigacion y Desarrollo en Ciencias de la Salud, Universidad Autonoma de Nuevo Leon, Carlos Canseco, S/N, Col. Mitras Centro, 64460 Monterrey, NL, Mexico

Received 31 October 2014; Revised 27 January 2015; Accepted 30 January 2015

Academic Editor: Olav Lapaire

Copyright © 2015 Idalia Garza-Veloz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C.-H. Pui, L. L. Robison, and A. T. Look, “Acute lymphoblastic leukaemia,” The Lancet, vol. 371, no. 9617, pp. 1030–1043, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. C.-H. Pui and S. Jeha, “New therapeutic strategies for the treatment of acute lymphoblastic leukaemia,” Nature Reviews Drug Discovery, vol. 6, no. 2, pp. 149–165, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. K. Nguyen, M. Devidas, S.-C. Cheng et al., “Factors influencing survival after relapse from acute lymphoblastic leukemia: a Children's Oncology Group study,” Leukemia, vol. 22, no. 12, pp. 2142–2150, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. C.-H. Pui, M. V. Relling, and J. R. Downing, “Acute lymphoblastic leukemia,” The New England Journal of Medicine, vol. 350, no. 15, pp. 1535–1548, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. SINAIS, SNdIeS: Principales causas de mortalidad en edad escolar (de 5 a 14 años), Nacional, 2008, http://sinais.salud.gob.mx/descargas/xls/m_008.xls.
  6. SINAIS, SNdIeS: Principales causas de mortalidad en edad productiva (de 15 a 64 años), Nacional, 2008, http://sinais.salud.gob.mx/descargas/xls/m_009.xls.
  7. G. D. Gary and R. Glen, “Acute leukemias,” in CANCER Principles & Practice of Oncology, vol. 2, pp. 2221–2265, Lippincott Williams & Wilkins, Philadelphia, Pa, USA, 8th edition, 2008. View at Google Scholar
  8. K. R. Schultz, D. J. Pullen, H. N. Sather et al., “Risk- and response-based classification of childhood B-precursor acute lymphoblastic leukemia: a combined analysis of prognostic markers from the Pediatric Oncology Group (POG) and Children's Cancer Group (CCG),” Blood, vol. 109, no. 3, pp. 926–935, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. M. J. Sorich, N. Pottier, D. Pei et al., “In vivo response to methotrexate forecasts outcome of acute lymphoblastic leukemia and has a distinct gene expression profile,” PLoS Medicine, vol. 5, no. 4, article e83, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. M. L. Den Boer, D. O. Harms, R. Pieters et al., “Patient stratification based on prednisolone-vincristine-asparaginase resistance profiles in children with acute lymphoblastic leukemia,” Journal of Clinical Oncology, vol. 21, no. 17, pp. 3262–3268, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. E.-J. Yeoh, M. E. Ross, S. A. Shurtleff et al., “Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling,” Cancer Cell, vol. 1, no. 2, pp. 133–143, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. H. Kang, I. M. Chen, C. S. Wilson et al., “Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia,” Blood, vol. 115, no. 7, pp. 1394–1405, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. D. Bhojwani, H. Kang, R. X. Menezes et al., “Gene expression signatures predictive of early response and outcome in high-risk childhood acute lymphoblastic leukemia: a Children's Oncology Group Study,” Journal of Clinical Oncology, vol. 26, no. 27, pp. 4376–4384, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Holleman, M. H. Cheok, M. L. den Boer et al., “Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment,” New England Journal of Medicine, vol. 351, no. 6, pp. 533–623, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Lugthart, M. H. Cheok, M. L. den Boer et al., “Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia,” Cancer Cell, vol. 7, no. 4, pp. 375–386, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. I. Iacobucci, C. Papayannidis, A. Lonetti, A. Ferrari, M. Baccarani, and G. Martinelli, “Cytogenetic and molecular predictors of outcome in acute lymphocytic leukemia: recent developments,” Current Hematologic Malignancy Reports, vol. 7, no. 2, pp. 133–143, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Zhang, C. G. Mullighan, R. C. Harvey et al., “Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group,” Blood, vol. 118, no. 11, pp. 3080–3087, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. C. G. Mullighan, “The molecular genetic makeup of acute lymphoblastic leukemia,” Hematology/the Education Program of the American Society of Hematology, vol. 2012, pp. 389–396, 2012. View at Google Scholar · View at Scopus
  19. F. G. H. Hill, S. Richards, B. Gibson et al., “Successful treatment without cranial radiotherapy of children receiving intensified chemotherapy for acute lymphoblastic leukaemia: results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI (ISRC TN 16757172),” British Journal of Haematology, vol. 124, no. 1, pp. 33–46, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. S. P. Hunger, L. Sung, and S. C. Howard, “Treatment strategies and regimens of graduated intensity for childhood acute lymphoblastic leukemia in low-ioncome countries: a proposal,” Pediatric Blood and Cancer, vol. 52, no. 5, pp. 559–565, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Smith, D. Arthur, B. Camitta et al., “Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia,” Journal of Clinical Oncology, vol. 14, no. 1, pp. 18–24, 1996. View at Google Scholar · View at Scopus
  22. K. J. Livak and T. D. Schmittgen, “Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method,” Methods, vol. 25, no. 4, pp. 402–408, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. T. D. Schmittgen and K. J. Livak, “Analyzing real-time PCR data by the comparative CT method,” Nature Protocols, vol. 3, no. 6, pp. 1101–1108, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. J. Finke, P. Ternes, W. Lange, R. Mertelsmann, and G. Dolken, “Expression of interleukin 10 in B lymphocytes of different origin,” Leukemia, vol. 7, no. 11, pp. 1852–1857, 1993. View at Google Scholar · View at Scopus
  25. W. Łuczyński, E. Iłendo, O. Kovalchuk et al., “Acute lymphoblastic leukaemia cells express CCR7 but not higher amounts of IL-10 after CD40 ligation,” Scandinavian Journal of Clinical and Laboratory Investigation, vol. 66, no. 8, pp. 695–704, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. A. Holleman, M. L. den Boer, M. H. Cheok et al., “Expression of the outcome predictor in acute leukemia 1 (OPAL1) gene is not an independent prognostic factor in patients treated according to COALL or St Jude protocols,” Blood, vol. 108, no. 6, pp. 1984–1990, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. B. B. Chen, J. R. Glasser, T. A. Coon et al., “F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation,” Blood, vol. 119, no. 13, pp. 3132–3141, 2012. View at Publisher · View at Google Scholar · View at Scopus
  28. C. Flotho, E. Coustan-Smith, D. Pei et al., “Genes contributing to minimal residual disease in childhood acute lymphoblastic leukemia: prognostic significance of CASP8AP2,” Blood, vol. 108, no. 3, pp. 1050–1057, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. Y. Jiao, L. Cui, C. Gao et al., “CASP8AP2 is a promising prognostic indicator in pediatric acute lymphoblastic leukemia,” Leukemia Research, vol. 36, no. 1, pp. 67–71, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. J. Roman-Gomez, A. Jimenez-Velasco, L. Cordeu et al., “WNT5A, a putative tumour suppressor of lymphoid malignancies, is inactivated by aberrant methylation in acute lymphoblastic leukaemia,” European Journal of Cancer, vol. 43, no. 18, pp. 2736–2746, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. D. Gary Gilliland and J. D. Griffin, “The roles of FLT3 in hematopoiesis and leukemia,” Blood, vol. 100, no. 5, pp. 1532–1542, 2002. View at Publisher · View at Google Scholar · View at Scopus